Sezvatinokura, mapfupa edu anova asina kusimba uye anogona kutyoka, uye marapirwo aripo iye zvino anogona kuwedzera huwandu hwemapfupa zvishoma. Dambudziko iri rinowanzoitika nekuti chikonzero chikuru che osteoporosis (kuderera kwehuremu hwemapfupa uye huwandu hwawo) hachizivikanwe.
Munguva pfupi yapfuura, vaongorori vekuAustralia vakaburitsa mhedzisiro yekutsvagisa kwesainzi muJournal of Gerontology: Series A: NMN inogona kuderedza kukwegura kwemasero emapfupa evanhu uye kukurudzira kuporesa kwemapfupa mumakonzo ane osteoporosis. "Zvakawanikwa zvinoratidza kuti NMN inoshanda uye inokwanisika yekurapa kudzivirira osteoporosis uye kuwedzera kuporesa kwemapfupa muvakuru vane osteoporosis," vanyori vakadaro.
一,NMNinokurudzira kudzorerwa kwemaosteoblasts uye inowedzera kukura kwemapfupa
Kufanana nedzimwe nhengo dziri mumuviri wemunhu, mapfupa anogadzirwa nemasero mapenyu. Nokudaro, mapfupa ekare uye akakuvara anogara achitsiviwa nemamwe matsva. Zvisinei, sezvatinokura, maosteoblast mashoma anowanikwa, chimwe chikonzero ndechekuti maosteoblast akajairwa anova masero achangotanga kuchembera. Masero achangotanga kuchembera, ayo anowanzo konzera kuchembera, haakwanise kuumba mapfupa matsva, zvichikonzera osteoporosis.
Vaongorori vekuAustralia vakadzidza migumisiro yeNMN pa osteoporosis nekudzidza nezve osteoblasts dzevanhu. Kuti vakwegure kukwegura, vaongorori vakaratidza osteoblasts kune chinhu chinokurudzira kuzvimba chinonzi TNF-⍺. Kunyangwe TNF-⍺ ichikurumidzisa kukwegura, kurapwa neNMN kwakaderedza kukwegura kanenge katatu, uye mhedzisiro yakaratidza kuti NMN yakaderedza osteoblasts dzinokura kukwegura.
Maosteoblast ane hutano anoumba mapfupa matsva nekushandura kuita masero emapfupa akura. Vaongorori vakaona kuti kukonzera kukwegura neTNF-⍺ kwakaderedza kuwanda kwemasero emapfupa akura. Zvisinei, NMN yakawedzera kuwanda kwemasero emapfupa akura, uye mhedzisiro yacho inoratidza kuti NMN inogona kukurudzira kuumbwa kwemapfupa.
Mushure mekunge zvabuda pachena kutiNMNVaongorori vakaedza kana izvi zvingaitika muzvinhu zvipenyu. Kuti vaite izvi, vakabvisa maovari emakonzo echikadzi ndokupwanya femur dzavo, zvichikonzera kurasikirwa kwemapfupa ayo anowanzoonekwa ne osteoporosis.
Kuti vaedze kushanda kweNMN pa osteoporosis, vaongorori vakabaya mbeva dze osteoporotic 400 mg/kg/zuva yeNMN kwemwedzi miviri. Zvakaonekwa kuti mbeva dzine osteoporosis dzakanga dzawedzera kuwanda kwemapfupa, zvichiratidza kuti NMN yakachinja zvishoma zviratidzo zve osteoporosis. Pamwe chete nedata rema osteoblast evanhu, izvi zvinoreva kuti NMN inogona kukwanisa kurapa osteoporosis nekuwedzera kuumbwa kwemapfupa.
二、 Bone-enhancing mhedzisiro yeNMN
Zvakabuda muongororo zvinoratidza kutiNMNinogona kukurudzira kuumbwa kwemapfupa. Zvinoita sekuti inoita izvi nenzira dzakasiyana-siyana, kusanganisira kudzorera masero emapfupa, ayo akakosha pakuumbwa kwemapfupa uye NAD+, iyo inokosha pakuumbwa kwemapfupa. Masero emapfupa anosiyana kuita maosteoblast, uye vaongorori vakaratidza kuti NMN inogonawo kudzoreredza maosteoblast.
Zvakawanikwa izvi zvinoratidza kuti NMN inogona kuwedzera kuumbwa kwemapfupa nekusimudzira hutano hwemasero akawanda emapfupa munzira yekuumbwa kwemapfupa. Kunyangwe pasina mhedzisiro yekutsvagisa inoratidza kuti NMN inogona kukurudzira kuumbwa kwemapfupa kune vanhu vane osteoporosis, zvinogoneka kuti NMN inogona kudzivirira kukura kwemapfupa kunoitika nekukwegura.
Nguva yekutumira: Ndira-18-2024