Clenbuterol, inonzi β2-adrenergic agonist (β2-adrenergic agonist), yakafanana ne ephedrine (Ephedrine), inowanzoshandiswa muchipatara kurapa chirwere chisingaperi chechirwere chemapapu (COPD), Inoshandiswawo sebronchodilator kuti isunungure kuwedzera kwakanyanya kweasthma.Mukutanga kwema1980, kambani yeAmerica Cyanamid yakaona netsaona kuti ine mhedzisiro iri pachena yekusimudzira kukura, kuvandudza nyama yakaonda uye kuderedza mafuta, saka yakashandiswa se clenbuterol mukuchengeta mhuka.Zvisinei, nokuda kwemigumisiro yayo, European Community yakarambidza kushandiswa kweclenbuterol sechikafu chekuwedzera kubva munaJanuary 1, 1988. Yakarambidzwa neFDA muna 1991. Muna 1997, Ministry of Agriculture yePeople's Republic of China yakarambidza zvakasimba. kushandiswa kwe beta-adrenergic mahomoni mukudyisa uye kugadzirwa kwemhuka, uye Clenbuterol hydrochloride iri pekutanga.
Zvisinei, racemic Clenbuterol ichangobva kuratidzwa kuderedza ngozi yechirwere cheParkinson.Kuti usimbise kuti (kana kuti zvose) isomers inobudisa ichi chiitiko, yakachena Clenbuterol enantiomer inoda kudzidzwa zvakasiyana.
Muchinyorwa chechangobva kuitika, boka rekutsvagisa raElisabeth Egholm Jacobsen weDhipatimendi reChemistry, Norwegian University of Science and Technology, pamwe chete naDr. Zhu Wei weShangke Bio, vakagadzira kuumbwa kweketoreductase KRED uye cofactor nicotinamide adenine dinucleoside phosphate (NADPH). )(R) -1-(4-Amino-3,5-dichlorophenyl) -2-bromoethan-1-ol, ee> 93%;uye (S)-N-(2 yakagadzirwa nehurongwa humwe ,6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee>98%.Zvose zviri pamusoro apa zvinogona kuva zvigadziridzo zve clenbuterol isomers.Ketoreductase ES-KRED-228 yakashandiswa muchidzidzo ichi yakabva kuShangke Biopharmaceutical (Shanghai) Co., Ltd. Mhedzisiro yekutsvakurudza "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" yakabudiswa mu "Catalysts" pa. Mbudzi 4, 2018.
Nguva yekutumira: Aug-26-2022