Clenbuterol, mushonga unoshanda seβ2-adrenergic agonist (β2-adrenergic agonist), wakafanana ne ephedrine (Ephedrine), unowanzoshandiswa mukurapa chirwere chemapapu chinogara kwenguva refu (COPD). Unoshandiswawo semushonga wekubvisa manyoka (bronchodilator) kuderedza kukwira kwechirwere cheasthma. Mukutanga kwema1980, kambani yekuAmerica inonzi Cyanamid yakawana netsaona kuti ine mhedzisiro yakajeka yekusimudzira kukura, kuvandudza mwero wenyama isina mafuta uye kuderedza mafuta, saka yakashandiswa se clenbuterol mukuchengeta mhuka. Zvisinei, nekuda kwemigumisiro yayo, European Community yakarambidza kushandiswa kwe clenbuterol sechikafu chekuwedzera kubva muna Ndira 1, 1988. Yakarambidzwa neFDA muna 1991. Muna 1997, Ministry of Agriculture yePeople's Republic of China yakarambidza zvachose kushandiswa kwemahormone e beta-adrenergic mukugadzira chikafu nekuchengeta mhuka, uye Clenbuterol hydrochloride ndiyo yaive yekutanga.
Zvisinei, Clenbuterol yerudzi rweracemic yakaratidzwa munguva pfupi yapfuura kuti inoderedza njodzi yechirwere cheParkinson. Kuti zvionekwe kuti ndeapi (kana ese ari maviri) isomers anogadzira izvi, Clenbuterol enantiomer yakachena inofanira kudzidzwa yoga.
Muchinyorwa chazvino, boka rekutsvagisa raElisabeth Egholm Jacobsen weDhipatimendi reChemistry, Norwegian University of Science and Technology, pamwe chete naDr. Zhu Wei weShangke Bio, vakakurudzira kugadzirwa kweketoreductase KRED uye cofactor nicotinamide adenine dinucleoside phosphate (NADPH). (R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%; uye (S)-N-(2 yakagadzirwa nesystem imwechete ,6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee >98%. Zvese zviri pamusoro apa zvinogona kukonzera clenbuterol isomers. Ketoreductase ES-KRED-228 yakashandiswa muchidzidzo ichi yakabva kuShangke Biopharmaceutical (Shanghai) Co., Ltd. Mhedzisiro yekutsvagisa "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" yakaburitswa mu "Catalysts" musi wa4 Mbudzi, 2018.
Nguva yekutumira: Nyamavhuvhu-26-2022