Molecular Metabolism: Therapeutic effect yeNMN supplementation pa polycystic ovary syndrome.

Mumakore achangopfuura, nekuwedzera kwemararamiro asina kunaka uye kuwedzera kwehutano hwemagariro evanhukadzi, chiitiko chepolycystic ovary syndrome (PCOS) chave chichiwedzera kuoneka.Ongororo dzekune dzimwe nyika dzakaratidza kuti chiitiko chepolycystic ovary syndrome (PCOS) muvakadzi vezera rekubereka chakakwira se6% -15%, nepo kuChina, chikamu chakakwira se6% -10%.

Polycystic ovary syndrome chirwere chinowanzoitika muvakadzi vezera rekubereka nekuda kwekukanganiswa kwe endocrine.Iyo inonyanya kuratidzwa mune isina kujairika glucose uye lipid metabolism uye kusashanda zvakanaka kwekubereka.Makiriniki ekuongorora maitiro ihomoni level disorder ( high androgen ), dilute Ovulation disorders uye ovarian polycystic shanduko, uye vakadzi vazhinji vane PC COS vane maitiro asina kunaka emagetsi, akadai se insulin resistance, kufutisa, uye hepatic steatosis.

Parizvino, kune mishonga mishoma yekurapa PCOS.Nzira yakajairika ndeyekuvandudza PCOS nekunanga uye kuvharidzira androgen yakawandisa nemishonga inorwisa-androgen.Zvisinei, panewo uchapupu hwokuti anti-androgen zvinodhaka zvine chiropa chakasimba chehutu, saka kushandiswa kwavo kunogumira.Nokudaro, zvakakosha zvikuru kutsvaga chinhu chechisikigo pasina migumisiro yekutsiva ikozvino mishonga.

ongororo ichangoburwa neYunivhesiti yeNew South Wales muAustralia yakawana kuti polycystic ovary syndrome yakabatana neNAD + kushomeka, uye mhedzisiro yekutsvaga yakabudiswa mumagazini yesainzi "Molecular Metabolism".

Boka rekutsvagisa rakatanga kuisa dihydrotestosterone (DHT) pasi pechikadzi mbeva pamberi uye mushure mekuyaruka kuti igadzire PC COS mbeva modhi, uyezve mushure memavhiki masere ekurapwa kweNMN, kutsanya insulin uye HOMA insulin resistance yekuona, glucose tolerance test, mafuta Mushure mekuedzwa kwakadaro. se histomorphometry, mhedzisiro yehuwandu inoratidza:

1. N MN inodzorera N AD + nhanho mumhasuru yeP COS mbeva
akawana kuti iyo NAD + nhanho mumhasuru yePCOS mbeva yakadzikira zvakanyanya, uye iyo NAD nhanho mumhasuru yePCOS mbeva yakadzoserwa neNMN yekudyisa.

2. NMN inovandudza insulin kudzivisa uye kuneta muPCOS mice
DHT-induced insulin mazinga anodarika zvakapetwa kaviri mukutsanya PCOS mbeva, pamwe ichiratidza insulin kuramba.Nekudyisa NMN, zvakaonekwa kuti kutsanya insulin level yakadzorerwa kusvika pamwero uri pedyo neyoyo yemakonzo.Mukuwedzera, huremu hwePCOS mbeva hwakawedzera ne20%, uye huwandu hwemafuta hwakawedzera zvakanyanya.

3. NMN inodzorera abnormal hepatic lipid deposition muPCOS mice
Humwe hunhu hwepolycystic ovary syndrome ndeye lipid deposition muchiropa uye kuiswa kwechiropa chine mafuta.Mushure mekutora NMN, iyo isina kujairika chiropa lipid deposition muPCOS mbeva yakanga yava kuda kubviswa, uye triglycerides muchiropa yakadzokera pamwero wemakonzo.

mhedziso, chiyero cheNAD + mumhasuru yePCOS chakaderedzwa zvakanyanya, uye mamiriro ePCOS akaderedzwa nekuwedzera NMN, inotangira NAD +, inogona kunge iri nzira yekurapa yekurapa PCOS.

mareferensi:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Kuderera mhasuru NAD + mune hyperandrogenism PCOS mbeva modhi: Inogoneka basa mu metabolic dysregulation.Mol Metab.2022 Sep 9;65:101583.doi: 10.1016/j.molmet.2022.101583.Epub pamberi pekudhindwa.PMID: 36096453.