Mumakore achangopfuura, nekuwedzera kwemararamiro asina kunaka uye kuwedzera kwekumanikidzwa kwevanhukadzi munharaunda, huwandu hwevanhu vanobatwa nechirwere chepolycystic ovary syndrome (PCOS) hwave pachena zvakanyanya. Zvidzidzo zvekune dzimwe nyika zvakaratidza kuti huwandu hwevanhu vanobatwa nechirwere chepolycystic ovary syndrome (PCOS) muvakadzi vari pazera rekubereka huri pa6% -15%, nepo muChina, huwandu hwacho huri pa6% -10%.
Polycystic ovary syndrome chirwere chinowanzoitika kuvakadzi vane zera rekubereka nekuda kwekusagadzikana kwe endocrine. Chinonyanya kuoneka mukusagadzikana kweglucose uye lipid metabolism uye kusashanda zvakanaka kwekubereka. Zvinodiwa pakuongorora chirwere ichi zvinosanganisira kusagadzikana kwemazinga ehomoni (high androgen), kusagadzikana kweOvulation disorders uye kuchinja kwe ovarian polycystic, uye vakadzi vazhinji vane PC COS vane zvinhu zvisina kunaka zve metabolic, zvakaita se insulin resistance, kufuta, uye hepatic steatosis.
Parizvino, kune mishonga mishoma yekurapa PCOS. Nzira yakajairika ndeyekuvandudza PCOS nekutarisa nekudzivirira kuwanda kwe androgen nemishonga inorwisa androgen. Zvisinei, kune humbowo hwekuti mishonga inorwisa androgen ine chepfu yakasimba muchiropa, saka kushandiswa kwayo kwakaganhurirwa. Saka, zvakakosha kutsvaga chinhu chechisikigo chisina mhedzisiro kuti chitsive mishonga iripo.
Ongororo yakaitwa munguva pfupi yapfuura neYunivhesiti yeNew South Wales muAustralia yakawana kuti polycystic ovary syndrome ine chekuita nekushaikwa kweNAD+, uye mhedzisiro yekutsvagisa yakaburitswa mujenari resainzi rinonzi "Molecular Metabolism".
Chikwata chekutsvagisa chakatanga chaisa dihydrotestosterone (DHT) pasi peganda rembeva dzechikadzi vasati vasvika uye mushure mekuyaruka kuti vagadzire modhi yembeva yePC COS, uye mushure memavhiki masere ekurapwa kweNMN, insulin yekutsanya uye HOMA insulin resistance detection, glucose tolerance test, mafuta. Mushure mekuyedzwa kwakadai sehistomorphometry, mhedzisiro yehuwandu inoratidza:
1. N MN inodzosera N AD + mwero mutsandanyama dzembeva dzeP COS
vakawana kuti huwandu hweNAD+ mumhasuru dzembeva dzePCOS hwakadzikira zvakanyanya, uye huwandu hweNAD mumhasuru dzembeva dzePCOS hwakadzorerwa nekudyisa NMN.
2. NMN inovandudza kuramba insulin uye kufuta mumakonzo ePCOS
Mazinga e insulin anokonzerwa neDHT akapetwa kaviri mumakonzo ePCOS anotsanya, zvichida zvichiratidza kusakwanisa kwe insulin. Nekupa NMN chikafu, zvakaonekwa kuti huwandu hwe insulin yekutsanya hwakadzorerwa padanho riri pedyo neremakonzo akajairwa. Pamusoro pezvo, huremu hwemuviri wemakonzo ePCOS hwakawedzera ne20%, uye mafuta akawedzera zvakanyanya.
3. NMN inodzorera kuiswa kwemafuta muropa mumbeva dzePCOS zvisina kujairika
Chimwe chezvinhu zvinoratidza polycystic ovary syndrome ndiko kuiswa kwemafuta muchiropa uye kupinza kwechiropa chine mafuta. Mushure mekutora NMN, kuiswa kwemafuta muchiropa mumbeva dzePCOS kwakapotsa kwapera, uye triglycerides muchiropa yakadzokera padanho remakonzo akajairika.
mhedziso, huwandu hweNAD+ mumhasuru yePCOS hwakaderedzwa zvakanyanya, uye mamiriro ePCOS akaderedzwa nekuwedzera NMN, iyo inotangira NAD+, iyo ingave nzira yekurapa inogona kushandiswa pakurapa PCOS.
mareferensi:
[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Kuderera kwetsandanyama NAD+ mu hyperandrogenism PCOS mouse model: Basa rinogona kuitika mukusagadzikana kwemetabolism. Mol Metab. 2022 Gunyana 9;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub isati yadhindwa. PMID: 36096453.
Nguva yekutumira: Mbudzi-17-2022