Oocyte ndiyo mavambo ehupenyu hwemunhu, izai risati rakura rinozopedzisira rakura kuita zai. Zvisinei, kunaka kweoocyte kunoderera sezvo vakadzi vachikura kana nekuda kwezvinhu zvakaita sekufuta, uye oocytes dzisina kunaka ndizvo zvinonyanya kukonzera kusabereka zvakanaka muvakadzi vakafuta. Zvisinei, maitiro ekuvandudza mhando yemaocytes muvakadzi vakafuta idambudziko kune masayendisiti.
Munguva pfupi yapfuura, chidzidzo chinonzi Administration of nicotinamide mononucleotide chinovandudza mhando yembeva dzakafuta chakaburitswa muchikamu chekuwedzera kwemasero. Chidzidzo ichi chakawana kuti kuwedzerwa kwe nicotinamide adenine dinucleotide (NAD+) kunotangira kukura kwembeva.nicotinamide mononucleosideAsidhi (NMN) inogona kuvandudza kuzvimba kwemazai, kuvandudza kunaka kwemazai uye kudzoreredza huremu hwemuviri wevana mumbeva dzechikadzi dzakafuta.
Vaongorori vakasarudza mbeva dzechikadzi dzine mavhiki matatu ekuberekwa nembeva dzechirume dzine vhiki gumi nerimwe dzekuberekwa kuti vagadzire muenzaniso wembeva wekufuta nekudya zvine mafuta akawanda uye zvakaongororwa nekunyora huremu, bvunzo yeglucose yeropa yekutsanya, uye bvunzo yekushivirira glucose nemuromo, kupindira mune zvekudya 1 Kwemavhiki maviri,NMNMishonga yekuwedzera yakabayiwa kwemazuva gumi akatevedzana kuti ione kuratidzwa kwemajini ane chekuita nekukura kweovarian uye majini ane chekuita nekuzvimba, saizi yemafuta emudumbu, huwandu hweokisijeni hunoshanda hwemaoocytes, chimiro chechromosome yespindle, Basa remitochondrial, actin dynamics, uye kukuvara kweDNA, zvichienzaniswa nemhedzisiro yehuwandu inoratidza:
1. Muenzaniso wembeva dzine mafuta akawanda unobva mukudya kwakawandisa wakagadzirwa zvinobudirira
Kukosha kweFGB kweboka revanhu vane chikafu chine mafuta akawanda (HFD) kwaive kwakakwira nguva dzose kupfuura kweboka revanhu vane chikafu chakajairika (ND), pamusoro pezvo, mhedzisiro yeOGTT yakaratidza kuti mbeva dzeboka revanhu vane chikafu chine mafuta akawanda (HFD) dzaisakwanisa kushivirira shuga.
2. NMN inogona kuvandudza kusagadzikana kwemetabolism mumakonzo eHFD
Kuwedzera pamwe cheteNMNkuwedzerwa kwemafuta kwakadzikisa huwandu hwemafuta mumakonzo ari muboka rekudya rine mafuta akawanda (HFD), uye mhedzisiro yacho inoratidza kuti NMN ine mhedzisiro yekudzivirira pakuchinja kwemuviri kusingawanzoitika mumakonzo ari muboka rekudya rine mafuta akawanda (HFD).
3. NMN inovandudza kunaka kwemazai mumbeva dzeHFD
NMN inogona kuvandudza kunaka kwemazai mumbeva dzine mafuta akawanda (HFD) nekutonga kuratidzwa kwemajini akakosha ane chekuita nekukura kwemazai (Bmp4, Lhx8) uye kuzvimba.
4. NMN inoderedza zvikanganiso zvekupatsanurwa kweoocyte uye kukuvara kweDNA mumakonzo eHFD
NMN inogona kuderedza kuwanda kwezvikanganiso zve spindle uye kusarongeka kwema chromosome kunokonzerwa nekudya kune mafuta akawanda (HFD), kuderedza γH2A.X signaling, uye kugadzirisa kukuvara kweDNA kunokonzerwa nekudya kune mafuta akawanda (HFD) nekuderedza Bax expression.
5. NMN inogona kuvandudza mhando yemaoocytes
NMN inogona kugadzirisa kuderedzwa kwekushandiswa kweSOD1 inorwisa mabhakitiriya muboka rekudya rine mafuta akawanda (HFD), kuvandudza kupararira kwemitochondria, uye inogona kuvandudza mhando yemaoocytes nekuchengetedza kusimba kwecytoskeleton.
6. NMN inogona kudzoreredza kupararira kwemafuta mumakonzo eHFD
Maoocyte eboka rekudya ane mafuta akawanda (HFD) aive akakwira zvishoma pane eboka rekudya kwakajairika (ND), uye kuwedzerwa kweNMN kunogona kuderedza kupenya kwemafuta mumadonhwe emafuta.
7. NMN inodzorera huremu hwemuviri muvana vembeva dzeHFD
Huremu hwekuzvarwa kwevana veboka rekudya rine mafuta akawanda (HFD) hwakanga hwakaderera zvakanyanya pane hweboka rekudya kwakajairika (ND), uye kuwedzerwa kweNMN kuwedzerwa kwakadzorera huremu hwekuzvarwa kwevana veboka reHFD.
Muchidzidzo ichi, vaongorori vakaratidza kuburikidza nekuyedza kwembeva kuti NMN ine kugona kuvandudza mhando yemaoocytes mumbeva dzechikadzi dzakafuta nekuda kwekudya kwakawanda, uye vakaratidza kuti NMN inogona kudzoreredza mashandiro emitochondrial uye kuderedza kuunganidzwa kweROS mumaocytes embeva dzechikadzi dzakafuta. , kukuvara kweDNA uye nzira dziri pasi pekugoverwa kwemadonhwe emafuta. Nokudaro, chidzidzo ichi chichapa nzira inogona kushandiswa pakurapa matambudziko ekubereka anokonzerwa nekufutisa muvakadzi.
mareferensi:
1.Wang L, Chen Y, Wei J, nevamwe. Kupiwa nicotinamide mononucleotide kunovandudza kunaka kwembeva dzakafuta. Cell Prolif. 2022; e13303. doi10. 1111cpr.13303
Nguva yekutumira: Gunyana-28-2022