Oocyte ndiko kutanga kwehupenyu hwemunhu, izera rezai risati rakura rinozopedzisira rakura kuita zai.Nekudaro, hunhu hweoocyte hunodzikira sezera revakadzi kana nekuda kwezvinhu zvakaita kufutisa, uye yakaderera-mhando oocyte ndiyo inonyanya kukonzera kuderera kwembereko muvakadzi vakafutisa.Nekudaro, maitiro ekuvandudza kunaka kwemaoocyte muvakadzi vakafuta idambudziko kune vesainzi.
Munguva pfupi yapfuura, chidzidzo chakanzi Administration nicotinamide mononucleotide inovandudza oocyte mhando yemakonzo akafuta yakaburitswa muSero kuwedzera.Chidzidzo ichi chakawana kuti kuwedzera nicotinamide adenine dinucleotide (NAD +) precursor.nicotinamide mononucleosideAcid (NMN) inogona kunyatso kuvandudza kuzvimba kweovarian, kuvandudza hunhu hweoocyte uye kudzoreredza huremu hwemuviri wevana mumakonzo echikadzi akafutisa.
Vatsvakurudzi vakasarudza 3-vhiki-ekare mbeva dzechikadzi uye 11 - vhiki-yekare mbeva dzechirume kuti dzigadzire mbeva yemhando yekufutisa nemafuta ane mafuta akawanda uye yakasimbiswa nekurekodha kurekodha, kutsanya kweropa glucose test, uye oral glucose tolerance test, kupindira kwekudya. 1 Kwemavhiki maviri,NMNmajekiseni akaiswa jekiseni kwemazuva gumi akatevedzana kuti aone kutaura kwemajini ane hukama nekukura kweovarian uye genes ane chekuita nekuzvimba, saizi yeabdominal adipose tissue, reactive oxygen mhando yemhando yeoocytes, spindlechromosome chimiro, mitochondrial Basa, actin dynamics, uye DNA kukuvadzwa, zvichienzaniswa nenhamba yabuda inoratidza:
1. A high-fat diet-induced obesity mouse model yakasimbiswa zvakabudirira
Nhamba yeFGB yeboka rekudya kwepamusoro-mafuta (HFD) yakaramba yakakwirira kudarika iyo yezvokudya zvakajairika (ND) boka, uyezve, migumisiro yeOGTT yakaratidza kuti kudya kwemafuta akawanda (HFD) mapoka emakonzo akanga asina glucose.
2. NMN inogona kuvandudza metabolic abnormalities muHFD mbeva
Kuwedzera neNMNsupplementation yakaderedza mafuta akawanda mumakonzo muboka rekudya kwemafuta akawanda (HFD), uye zvigumisiro zvinoratidza kuti NMN ine simba rekudzivirira pakusagadzikana kwemasabolism mumakonzo mukudya kwemafuta akawanda (HFD) boka.
3. NMN inovandudza ovarian quality muHFD mbeva
NMN inogona kuvandudza ovarian quality mukudya kwepamusoro-mafuta (HFD) mice nekugadzirisa kutaura kwemajini anokosha ane chokuita neovarian follicle development (Bmp4, Lhx8) nekuputika.
4. NMN inoderedza kukanganiswa kweoocyte division uye DNA kukanganisa muHFD mice
NMN inogona kuderedza kuwanda kwepamusoro-soro yezvinokanganisa uye chromosomal misalignments inokonzerwa ne-high-fat diet (HFD), kuderedza γH2A.X kuisa chiratidzo, uye kusimudzira kudya kwemafuta akawanda (HFD) -induced DNA kukanganisa nekuderedza Bax expression.
5. NMN inogona kuvandudza hutano hweoocytes
NMN inogona kugadzirisa pasi-inogadziriswa kutaura kwe antioxidant SOD1 mu-high-fat diet (HFD) boka, kuvandudza kugoverwa kwemitochondria, uye inogona kuvandudza hutano hweoocyte nekuchengetedza kuvimbika kwe cytoskeleton.
6. NMN inogona kudzorera lipid droplet kugoverwa muHFD mbeva
high-fat diet (HFD) boka oocyte rakanga rakakwirira zvishoma kudarika iro muzvokudya zvakajairika (ND) boka reoocyte, uye NMN supplementation inogona kuderedza fluorescence intensity ye lipid droplets.
7. NMN inodzorera huremu hwemuviri muvana veHFD mbeva
uremu hwekuzvarwa kwevana veboka rekudya kwemafuta akawanda (HFD) raive rakaderera zvakanyanya pane iro rekudya kwakajairika (ND) boka, uye kuwedzera neNMN kuwedzera kwakadzoreredza uremu hwekuzvarwa kwevana veboka reHFD.
Muchidzidzo ichi, vatsvakurudzi vakaratidza kuburikidza nekuedza kwembeva kuti NMN yakakwanisa kuvandudza kunaka kwemaoocyte mumakonzo echikadzi akafutisa anokonzerwa nekudya kwemafuta akawanda, uye akazivisa kuti NMN inogona kudzoreredza mitochondrial basa uye kuderedza kuunganidzwa kweROS mumakonzo echikadzi maoocyte., DNA kukuvadzwa uye nzira dziri pasi pe lipid droplet distribution.Naizvozvo, chidzidzo ichi chinopa nzira yekurapa inogona kuvandudza matambudziko embereko anokonzerwa nekufutisa muvakadzi.
zvinongedzo:
1.Wang L, Chen Y, Wei J, nevamwe.Kutungamirirwa kwe nicotinamide mononucleotide kunovandudza oocyte mhando yemakonzo akafuta.Cell Prolif.2022;e13303.doi10.1111cpr.13303
Nguva yekutumira: Sep-28-2022