NMN inoderedza radiation-induced intestinal fibrosis nekugadzirisa gut microbiota.

Radiation-induced intestinal fibrosis idambudziko rakajairika revanorarama kwenguva refu mushure memudumbu uye pelvic radiotherapy.Parizvino, hapana nzira yekiriniki inowanikwa yekurapa radiation-induced intestinal fibrosis.Zvidzidzo zvakaratidza kuti nicotinamide mononucleotide (NMN) ine mukana wekugadzirisa maruva emukati.Intestinal flora ndeye yakajairika microorganism mumatumbo emunhu, iyo inogona kugadzira zvakasiyana siyana zvinovaka muviri zvakakosha mukukura nekukura kwevanhu.Kana iyo intestinal flora isingaenzaniswi, inokonzera zvirwere zvakasiyana-siyana.
Munguva pfupi yapfuura, China Academy yeMedical Sciences uye Peking Union Medical College yakaburitsa tsvakiridzo mujenari International Journal yeRadiation Biology, iyo yakaratidza kuti NMN inogona kuderedza intestinal fibrosis inokonzerwa nemwaranzi nekudzora maruva emudumbu.
Pakutanga, boka rekutsvakurudza rakapatsanura mbeva kuita boka rekutonga, boka reNMN, boka reIR neboka reNMNIR, uye rakapa 15 Gy abdominal irradiation kuboka reIR neboka reNMNIR.Zvichakadaro, NMN yekuwedzera yakapihwa kuboka reNMN neboka reNMNIR padanho rezuva nezuva re300mg/kg.Mushure mekuitora kweimwe nguva yenguva, nekuona tsvina yemakonzo, intestinal microflora uye colon tissue marker, mhedzisiro yekufananidza yakaratidza kuti:

1. NMN inogona kugadzirisa kuumbwa uye kushanda kwemaruva emukumbo iyo inovhiringidzika nemwaranzi.
Nokuenzanisa kuonekwa kwemaruva emukati pakati peboka re IR neboka reNMNIR, zvakaonekwa kuti IR boka mbeva dzakawedzera kuwanda kwemaruva anokuvadza emukati, akadai saLactobacillus du, Bacillus faecalis, etc. Zvinoshamisa kuti boka reNMNIR mbeva dzakashandura kusiyana kwemaruva emukati. uye yakawedzera kuwanda kwemaruva anobatsira ematumbo, akadai seAKK mabhakitiriya, nekuwedzera NMN.Ongororo dzinoratidza kuti NMN inogona kugadzirisa kuumbwa uye kushanda kwemaruva emudumbu ayo asina kuenzana nekuda kwemwaranzi.

2. NMN inoderedza intestinal fibrosis inokonzerwa nemwaranzi
Iyo level yeSMA (Fibrosis Marker) mumakonzo akafumurwa nemwaranzi yakawedzera zvakanyanya.Mushure mekuwedzera kweNMN, kwete chete chiyero cheSMA marker chakaderera zvakanyanya, asiwo chinokonzera kuputika TGF-b iyo yakakurudzira intestinal fibrosis yakaderera zvikuru, zvichiratidza kuti NMN supplementation inogona kuderedza intestinal fibrosis inokonzerwa nemagetsi.

(Mufananidzo 1. NMN kurapwa inoderedza intestinal fibrosis inokonzerwa nemwaranzi)

Pasi pemamiriro ekupararira kwezvigadzirwa zvemagetsi, radiation ine kuwedzera kwekuita pabasa revanhu uye hupenyu, kunyanya pamatumbo emaruva kwenguva yakareba.NMN ine simba rakasimba rekudzivirira pahutano hwematumbo.Mhedzisiro iyi haisi kungoonekwa chete nechinhu chimwe chete kana imwe nzira, asiwo nekugadzirisa kugovera chimiro chemaruva kusimudzira kugadzikana kwekuita kwematumbo kubva kumakona akasiyana-siyana uye nzira, iyo inopawo chirevo chakakosha kune zvakasiyana-siyana zvinobatsira zveNMN.

References:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN inoderedza mwaranzi-induced intestinal fibrosis ne modulating gut microbiota, International Journal of Radiation Biology, DOI: 10.10530292.