Kubatwa nemwaranzi inokonzerwa nemwaranzi idambudziko rinowanzoitika kune vanorarama kwenguva refu mushure mekurapwa nemwaranzi mudumbu nemuchiuno. Parizvino, hapana nzira iripo yekurapa inokonzerwa nemwaranzi inokonzerwa nemwaranzi. Zvidzidzo zvakaratidza kuti nicotinamide mononucleotide (NMN) ine simba rekugadzirisa maruva emudumbu. Miriwo yemudumbu ibhakitiriya rakajairika muura hwemunhu, rinogona kugadzira zvinovaka muviri zvakasiyana-siyana zvinodiwa pakukura kwemunhu. Kana maruva emudumbu asina kuenzana, anokonzera zvirwere zvakasiyana-siyana.
Munguva pfupi yapfuura, China Academy of Medical Sciences nePeking Union Medical College vakaburitsa mhedzisiro yekutsvagisa mujenari reInternational Journal of Radiation Biology, iro rakaratidza kuti NMN inogona kuderedza fibrosis yemudumbu inokonzerwa nemwaranzi nekutonga maruva emudumbu.
Pakutanga, chikwata chekutsvagisa chakapatsanura mbeva muboka rekudzora, boka reNMN, boka reIR neboka reNMNIR, uye vakapa 15 Gy abdominal irradiation kuboka reIR neboka reNMNIR. Panguva iyi, NMN supplement yakapihwa kuboka reNMN neboka reNMNIR pachiyero chezuva nezuva che300mg/kg. Mushure mekuitora kwenguva yakati, nekuona tsvina yembeva, microflora yemudumbu uye zviratidzo zvematumbu emukati, mhedzisiro yekuenzanisa yakaratidza kuti:
1. NMN inogona kugadzirisa maumbirwo uye mashandiro emiti yemudumbu iyo inokanganiswa nemwaranzi.
Nekuenzanisa kuwanikwa kwezvirimwa zvemudumbu pakati peboka reIR neboka reNMNIR, zvakaonekwa kuti mbeva dzeboka reIR dzakawedzera huwandu hwezvirimwa zvinokuvadza mudumbu, zvakaita seLactobacillus du, Bacillus faecalis, nezvimwewo. Zvinoshamisa kuti mbeva dzeboka reNMNIR dzakachinja kusiyana kwezvirimwa zvemudumbu uye dzakawedzera huwandu hwezvirimwa zvinobatsira mudumbu, zvakaita seAKK bacteria, nekuwedzera NMN. Kuedza kunoratidza kuti NMN inogona kugadzirisa chimiro uye mashandiro ezvirimwa zvemudumbu izvo zvisina kuenzana nekuda kwemwaranzi.
2. NMN inoderedza fibrosis yemudumbu inokonzerwa nemwaranzi
Huwandu hweaSMA (Fibrosis Marker) mumakonzo akabatwa nemwaranzi hwakawedzera zvakanyanya. Mushure mekuwedzerwa kweNMN, huwandu hweaSMA marker hwakaderera zvakanyanya, asiwo chinhu chinokonzeresa kuzvimba chinonzi TGF-b icho chaikurudzira fibrosis yemudumbu chakaderera zvakanyanya, zvichiratidza kuti kuwedzerwa kweNMN kunogona kuderedza fibrosis yemudumbu inokonzerwa nemwaranzi.
(Mufananidzo 1. Kurapwa kweNMN kunoderedza fibrosis yemudumbu inokonzerwa nemwaranzi)
Zvichitevera kuwanda kwezvinhu zvemagetsi, mwaranzi ine simba guru pabasa revanhu nehupenyu hwavo, kunyanya pamiti yemudumbu kwenguva yakareba. NMN ine simba guru rekudzivirira hutano hwemudumbu. Izvi hazvingoonekwi nechinhu chimwe chete kana nzira imwe chete, asiwo nekudzora kupararira kwemiti kuti zvikurudzire kugadzikana kwebasa remudumbu kubva kumativi akasiyana-siyana, izvo zvinopawo chiratidzo chakakosha chekubatsira kwakasiyana-siyana kweNMN.
Mareferensi:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN inoderedza mwaranzi-induced intestinal fibrosis ne modulating gut microbiota, International Journal of Radiation Biology, DOI: 10.10530292.
Nguva yekutumira: Zvita-08-2022