Research Express | Ongororo yeYunivhesiti yeTsinghua inoratidza kuti NMN inogona kurapa kuzvimba

Kushanda kweMacrophage inzira inokonzera kuzvimba kwenguva refu mumuviri, asi kushanda kweMacrophage nguva dzose kunogona kutungamira kuzvimba kwenguva refu nezvirwere zvakaita sekuramba insulin uye zvirwere zvakakomba zvakaita se atherosclerosis. PGE 2, iyo inomiririra mhinduro yekuzvimba, inogadzirwa kubva kuarachidonic acid ne cyclooxygenases (COX-1 na COX-2). COX-1 naCOX-2 ndizvo zvinonyanya kurwiswa nekurwisa kuzvimba uye zvinogona kudziviswa nemishonga isiri yesteroidal anti-inflammatory (NSAIDs).

Kushandisa NSAIDs kunogona kukonzera matambudziko akawanda, akadai sekubuda ropa mudumbu. Saka, zvakakosha kuwana mushonga wechisikigo wakachengeteka wekurapa kuzvimba.

Munguva pfupi yapfuura, chikwata chekutsvagisa kubva kuTsinghua University chakarapa macrophages embeva neNMN, uye chakaratidza kuburikidza nekuyedza kuti NMN inogona kuderedza kuunganidzwa kwemapuroteni ane chekuita nekuzvimba uye zvigadzirwa zve metabolic, uye kudzivirira kupindura kwekuzvimba kwemacrophages. Frontiers in Molecular Biosciences.

Kuzvimba kunochinja huwandu hwezvinhu zvinogadzirwa mumacrophages
Kutanga, timu yekutsvagisa yakamutsa macrophages kuti agadzire kuzvimba kuburikidza ne lipopolysaccharide (LPS), uye yakazoongorora huwandu hwezvigadzirwa zvakatenderedza macrophages panguva yekuzvimba. Mazinga e99 metabolites akawedzerwa uye 105 metabolites akadzikiswa pakati pemamorekuru 458 akaonekwa asati akurudzirwa kuzvimba uye mushure mekukurudzirwa kuzvimba, uye mazinga eNAD+ anoenderana nekuzvimba akadzikiswawo.

(Mufananidzo 1)

NMN inowedzera mazinga eNAD uye inoderedza kuzvimba kwe macrophage
Chikwata chekutsvagisa chakazorapa macrophages neLPS, izvo zvinokonzeresa kuzvimba, IL-6 neIL-1β, ma cytokines anokonzera kuzvimba anoshanda sezviratidzo zvekuzvimba. Mushure mekurapwa kweNMN kwekuzvimba kweLPS-induced macrophage, zvakaonekwa kuti huwandu hweNAD hwemukati memasero hwakawedzera uye mRNA expression yeIL-6 neIL-1β yakadzikira. Kuedza kwakaratidza kuti NMN yakawedzera huwandu hweNAD uye kuderedza kuzvimba kweLPS-induced macrophage.

(Mufananidzo 2)

(Mufananidzo 3)

NMN inoderedza mazinga emapuroteni ane chekuita nekuzvimba
Pakurapwa kweNMN, zvakaonekwa kuti mapuroteni ane chekuita nekuzvimba akadai seRELL1, PTGS2, FGA, FGB uye igkv12-44 akadzikira mumasero, izvo zvakaratidza kuti NMN yakaderedza kuratidzwa kwemapuroteni ane chekuita nekuzvimba.

(Mufananidzo 4)

NMN inoderedza kuratidzwa kwemapuroteni eNSAIDS
Kuedza kwekupedzisira kwakawana kuti NMN yakaderedza huwandu hwePGE2 mumasero eRAW264.7 anoshandiswa neLPS nekuderedza huwandu hweCOX-2, nokudaro ichideredza huwandu hweCOX2 uye ichidzivisa kuzvimba kunokonzerwa neLPS.

(Mufananidzo 6)

mhedziso, kuwedzerwa kweNMN kunogona kurapa kuzvimba kusingaperi mumakonzo, uye kurapwa kwekuzvimba muvanhu kuchiri kufanira kusimbiswa nemiedzo yekiriniki yakakodzera. Pamwe NMN ichava imwe nzira yeNSAIDS munguva pfupi iri kutevera.

mareferensi:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Inoderedza LPS-Induced Inflammation uye Oxidative Stress kuburikidza neKuderedza COX-2 Kuratidzwa muMacrophages. Mberi Mol Biosci. 2021 Jul 6.