Macrophage activation ndeye pathogenic nzira inotungamira mukuzvimba kusingaperi mumuviri, asi kuramba kuchiita macrophage activation kunogona kutungamirira mukuzvimba kusingaperi uye zvirwere zvakaita se insulin kuramba uye zvirwere zvakakomba senge atherosclerosis.PGE 2, iyo inopindirana nemhinduro yekuputika, inogadzirwa kubva arachidonic acid ne cyclooxygenases (COX-1 uye COX-2).COX-1 uye COX-2 ndiyo inonyanya kutariswa yekurwisa-kuzvimba uye inogona kudziviswa neasiri-steroidal anti-inflammatory drugs (NSAIDs).
Kushandisa NSAIDs kunogona kukonzera kukanganisa kwakawanda, sekubuda ropa mudumbu.Naizvozvo, zvinonyanya kukosha kuwana yakachengeteka zvakasikwa zvinhu kurapa kuzvimba .
Munguva ichangopfuura, boka rekutsvagisa kubva kuYunivhesiti yeTsinghua rakabata mbeva macrophages neNMN, uye yakaratidza kuburikidza nekuedza kuti NMN inogona kuderedza kuunganidzwa kwemapuroteni ane chekuita nekuzvimba uye metabolic byproducts, uye inhibisa kuputika kwekupindura kwema macrophages.Miganhu muMolecular Bioscience .
Kuzvimba kunoshandura mazinga e metabolic byproducts mu macrophages
Chekutanga, timu yekutsvagisa yakagadzira macrophages kuti ibudise kuzvimba kuburikidza ne lipopolysaccharide (LPS), uye ndokuongorora zviri mukati mezvibodzwa zvakatenderedza macrophages panguva yekuzvimba.Iwo mazinga e99 metabolites akawedzerwa uye 105 metabolites akadzikiswa pakati pemamorekuru mazana mana nemakumi mashanu akaonekwa pamberi uye mushure mekukurudzira kuzvimba, uye mazinga eNAD + anoperekedza kuzvimba akadzikirawo.
(MUFANANIDZO 1)
NMN inowedzera NAD mazinga uye inoderedza macrophage kuzvimba
Chikwata chekutsvagisa chakabva chabata macrophages neLPS, izvo zvinoita kuti pave nekuzvimba, IL-6 uye IL-1β, pro-inflammatory cytokines inoshanda sezviratidzo zvekuzvimba.Mushure meNMN kurapwa kweLPS-induced macrophage inflammation, yakawanikwa kuti intracellular NAD level yakawedzerwa uye mRNA kutaura kweIL-6 uye IL-1β yakaderedzwa.Ongororo dzakaratidza kuti NMN yakawedzera mwero weNAD uye yakadzikira LPS-induced macrophage kuzvimba.
(Mufananidzo 2)
(Mufananidzo 3)
NMN inoderedza mazinga eprotein ane chokuita nekuputika
NMN kurapwa, yakawanikwa kuti mapuroteni ane chokuita nekuputika akadai RELL1, PTGS2, FGA, FGB uye igkv12-44 yakaderedzwa mumasero, iyo yakaratidza kuti NMN yakaderedza kutaura kwezvipembenene zvine chokuita nekuputika.
(Mufananidzo 4)
NMN inoderedza kutaura kweNSAIDS yakananga mapuroteni
Kuedza kwekupedzisira kwakawana kuti NMN yakaderedza chiyero chePGE2 muLPS-yakagadzirwa RAW264.7 masero nekuderedza chiyero chekutaura kwe COX-2, nokudaro kuderedza kutaura kwe COX2 uye kudzivisa LPS-induced inflammation.
(Mufananidzo 6)
mhedziso, kuwedzera kweNMN kunogona kunyatso kurapa kuzvimba kusingaperi mumakonzo, uye kurapwa kwekuzvimba muvanhu kuchiri kuda kusimbiswa nemiedzo yekiriniki yakakodzera.Zvichida NMN ichave inotsiva NSAIDS munguva pfupi iri kutevera.
mareferensi:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Inoderedza LPS-Induced Inflammation uye Oxidative Stress kuburikidza neKuderedza COX-2 Kuratidzwa muMacrophages.Mberi Mol Biosci.2021 Jul 6.
Nguva yekutumira: Nov-26-2022