Hypopigmentation chirwere cheganda, chinonyanya kuratidzwa nekudzikira kwe melanin. Zviratidzo zvinowanzoonekwa zvinosanganisira vitiligo, albinism uye hypopigmentation mushure mekuzvimba kweganda. Parizvino, mushonga mukuru wehypopigmentation mushonga wemuromo, asi mushonga wemuromo unokonzera kupera kweganda, kusagadzikana kwemudumbu nezvimwe zvinokanganisa. Saka, zvakakosha kugadzira chinhu chechisikigo chisina migumisiro yekurapa hypopigmentation.
Munguva pfupi yapfuura, Scientific Reports yakaburitsa chinyorwa chine musoro unoti "Kuongorora kwakarongeka kunoratidza kugona kwespermidine pakurapa nekuderedza pigmentation | kuburikidza nekudzikamisa mapuroteni ane chekuita nemelanogeneis". Mhedzisiro yacho inoratidza kuti spermidine inogona kurapwa nekudzikamisa mapuroteni ane chekuita nemelanogeneis.
Kurapa kweSpermidine kunowedzera kugadzirwa kwemelanin
Kuti vaongorore mashandiro anoita spermidine pakugadzirwa kwemelanin, timu yekutsvagisa yakarapa melanin mumasero eMNT-1 nemazinga akasiyana espermidine. Kuburikidza nekuongorora huwandu, zvakaonekwa kuti kurapwa kwespermidine kwakawedzera kugadzirwa kwemelanin.
Zvino, Spermidine inogona kudzora hurongwa hwekuora kwemapuroteni hune chekuita ne melanogenesis
Kuti varatidze kuti spermidine inogona kudzora majini ane chekuita nekuora kwemapuroteni, chikwata chekutsvagisa chakawana majini 181 asina kudzorwa uye majini 82 akawedzerwa achidzorwa nekuona masero akarapwa nespermidine, kusabatanidza majini ane chekuita ne melanogenesis. Kuti vawedzere kuratidza, chikwata chekutsvagisa chakaongorora mhedzisiro ye spermidine pahuwandu hwekutaura kwemhuri yemajini e tyrosinase TYR, TRP-1 na TRP-2, ayo ari majini anodzora kugadzirwa kwe melanin zvakanyanya. Huwandu hwekutaura kwe mRNA hwakasimbisa kuti spermidine haina kuchinja kuratidzwa kwemajini ane chekuita ne melanogenesis. Zvisinei, mashandiro emajini akati wandei anochinjwa ne spermidine uye ane chekuita nekuora kwemapuroteni. Majini akati wandei akachinjwa ane chekuita ne ubiquity, inova system yekuora kwemapuroteni ine chekuita ne melanogenesis.
三．Spermidine inodzora kugadzikana kwemapuroteni uye inokurudzira kugadzirwa kwemelanin.
Kugadzirwa kwemelanin kunodzorwa nekuenzana kwekugadzirwa uye kuputsika kwemapuroteni ane chekuita nemelanin. Spermidine inobata majini eTYR, TRP-1 neTRP-2. Kuburikidza nekushanda kwemajini ekutakura SLC3A2, SLC7A1, SLC18B1 neSLC22A18, inogona kuwedzera huwandu hwemapolyamines mumasero, nokudaro ichiwedzera kugadzikana kwemapuroteni ane chekuita nekugadzirwa kwemelanin kukurudzira kugadzirwa kwemelanin mumuviri.
Mukupedzisa, chidzidzo ichi chinoratidza kuti spermidine yechisikigo ine basa guru mukurapa hypopigmentation, uye ine kukosha kwakati kuti kushandiswa kwayo mumunda wezvizoro nemishonga yehutano mune ramangwana.
Chirevo:
[1].Brito, S., Heo, H., Cha, B. nevamwe. Kuongorora kwakarongeka kunoratidza kugona kwespermidine pakurapa hypopigmentation kuburikidza nekugadzikana kwemapuroteni ane chekuita nemelanogenesis.Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Nguva yekutumira: Gunyana-28-2022