Hypopigmentation chirwere cheganda, chinonyanya kuratidzwa nekuderedza melanin.Zviratidzo zvakajairika zvinosanganisira vitiligo, albinism uye hypopigmentation mushure mekuputika kweganda.Parizvino, mushonga mukuru we hypopigmentation mushonga wemuromo, asi mushonga wemuromo unokonzera ganda atrophy, gastrointestinal kusagadzikana uye mamwe maitiro akaipa.Naizvozvo, zvinodikanwa kugadzira chinhu chechisikigo pasina mhedzisiro yekurapa hypopigmentation.
Munguva ichangopfuura, Scientific Reports yakabudisa nyaya ine musoro unoti "Kuongorora kwakarongeka kunoratidza kukwanisa kwespermidine ye hypopigmentation treatment | kuburikidza nekugadzikana kwemapuroteni ane melanogenesis".Mhedzisiro yacho inoratidza kuti spermidine inogona kurapwa nekudzikamisa melanogenesis-inosanganiswa mapuroteni.hypopigmentation.
一、Spermidine kurapwa kunowedzera kugadzirwa kwe melanin
Kuti tidzidze maitiro espermidine pakugadzirwa kwe melanin, timu yekutsvagisa yakabata melanin muMNT-1 maseru ane huwandu hwakasiyana hwespermidine.Kuburikidza nekuongorora kwehuwandu, zvakaonekwa kuti kurapwa kwespermidine kwakawedzera kugadzirwa kwe melanin.
二、Spermidine inogona kudzora mapuroteni ekuora system ane hukama ne melanogenesis
Kuitira kuratidza kuti spermidine inogona kudzora majini anobatanidzwa mukuora kweprotein, boka rekutsvagisa rakawana 181 majini pasi akadzorwa uye 82 majini kumusoro anodzorwa nekuona zvakarongeka masero akabatwa nespermidine, kusasanganisa majini ane chekuita nemelanogenesis.Kuti uwedzere kuratidza, timu yekutsvagisa yakaongorora maitiro espermidine padanho rekutaura re tyrosinase gene mhuri TYR, TRP-1 uye TRP-2, ari majini anonyatso kudzora kugadzirwa kwe melanin.Iyo mRNA yekutaura level yakasimbisa kuti spermidine haina kushandura kutaura kwe melanogenesis ine hukama genes.Zvisinei, basa remajini akawanda rinochinjwa ne spermidine uye rine chokuita neprotein degradation.Majene akati wandei ane hukama nekuzara, inova protein degradation system ine hukama ne melanogenesis.
三．Spermidine inodzora kugadzikana kwemapuroteni uye inosimudzira kugadzirwa kwe melanin.
Kugadzirwa kwe melanin kunodzorwa nechiyero che synthesis uye kuderedzwa kwe melanin ine hukama mapuroteni.Spermidine inobata TYR, TRP-1 uye TRP-2 majini.Kuburikidza nekuita kwemutakuri majini SLC3A2, SLC7A1, SLC18B1 uye SLC22A18, inogona kuwedzera huwandu hwema polyamines mumasero, nekudaro kuwedzera kugadzikana kwemapuroteni ane chekuita nekugadzirwa kwe melanin kukurudzira kugadzirwa kwe melanin mu vivo.
Mukupedzisa, chidzidzo ichi chinoratidza kuti yakasikwa compound spermidine ine basa rinokwanisa mukurapa hypopigmentation, uye ine imwe kukosha kwekushandisa mumunda wezvizoro uye zvigadzirwa zvehutano mune ramangwana.
Reference
[1].Brito, S., Heo, H., Cha, B. et al.Kuongorora kwakarongeka kunoratidza kukwanisa kwespermidine ye hypopigmentation kurapwa kuburikidza nekugadzikana kwe melanogenesis-associated proteins.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Nguva yekutumira: Sep-28-2022