β-Nicotinamide adenine dinucleotide (yemahara asidhi) (NAD)
NAD inonyanyozivikanwa coenzyme ye dehydrogenase mune zvipenyu.Inotora chikamu mukuita redox muzvisikwa zvipenyu, uye inotakura uye inotamisa maerekitironi kune zvinhu zviri mukuita.Dehydrogenase inotora chikamu chakakosha mumetabolism yevanhu.Mamwe mafambisirwo emagetsi emuviri wemunhu, akadai sekuora kweprotein, kuora kwecarbohydrates, uye kuora kwemafuta, hazvigone kuitwa zvakajairwa pasina dehydrogenase, uye vanhu vanorasikirwa nezviratidzo zvakakosha.Uye nekuti musanganiswa weNAD uye dehydrogenase unogona kusimudzira metabolism, saka NAD chikamu chakakosha chemuviri wemunhu.Zvinoenderana nekushandiswa kwechigadzirwa, inogona kukamurwa kuita anotevera giredhi: biotransformation giredhi, diagnostic reagent giredhi, hutano chikafu giredhi, API uye kugadzirira raw materials.
| Chemical Name | Nicotinamide adenine dinucleotide (yemahara asidhi) |
| Mashoko anoreva zvakafanana | β-Nicotinamide adenine dinucleotide |
| Nhamba yeCAS | 53-84-9 |
| Molecular Weight | 663.43 |
| Molecular Formula | C21H27N7O14P2 |
| EINECS 号: | 200-184-4 |
| Melting point | 140-142 °C (kuparara) |
| kuchengetedza temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | Upfu |
| color | Chena |
| Merck | 14,6344 |
| BRN | 3584133 |
| Kugadzikana: | Yakagadzikana.Hygroscopic.Hazvienderani neakasimba oxidizing agents. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Test Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kusvika kunze-chena crystalline poda |
| UV spectral analysis εpa260 nm uye pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Solubility | 25mg/mL 25mg/mL mumvura |
| Content (ne enzymatic analysis neADH pa pH 10, uchishandisa spectrophotometer, abs.340nm, pane anhydrous basis) | ≥98.0% |
| Assay (neHPLC, pane anhydrous basis) | 98.0~102.0% |
| Kuchena (neHPLC, % nzvimbo) | ≥99.0% |
| Zvemumvura (neKF) | ≤3% |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Ramba wakanyatsomira murima, kuitira kuchengetedza kwenguva refu gara pa2 ~ 8 ℃.
Biotransformation giredhi: Inogona kushandiswa biocatalytic synthesis yemishonga yepakati uye APIs, kunyanya ine catalytic enzymes, senge ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), glucose dehydrogenase ( GDH), nezvimwewo, izvo zvinogona kushandirapamwe kushandura akasiyana amino acid epakati uye mamwe ane hukama zvinodhaka.Parizvino, mafekitori mazhinji emishonga emudzimba atanga kushandisa biological enzyme kutsiva, uye kudiwa kwemusika kweNAD + kuri kukura nekukurumidza.
Diagnostic reagent giredhi: Yakasanganiswa neakasiyana ekuongorora enzymes, seyakaomeswa yekuongorora kits.
Utano hwekudya giredhi: NAD ndeye coenzyme ye dehydrogenase.Inobata basa risingadzoreki mu glycolysis, gluconeogenesis, iyo tricarboxylic acid kutenderera, uye cheni yekufema, inoita basa rakakosha mukugadzirwa kwesimba, uye inobatsira mukugadzirwa kweL-dopa, inova dopamine Neurotransmitters.Kunyanya mumakore achangopfuura, zvakaonekwa kuti ndiyo "injini" uye "mafuta" mukugadzirisa kukuvara kwesero.Zvinoenderana netsvagiridzo, kuwedzererwa kwecoenzymes (kusanganisira NMN, NR, NAD, NADH) mu vitro inogona kuwedzera iyo antioxidant simba rematishu maseru, inhibit apoptosis kusaina, kudzoreredza sero basa, kudzivirira kuitika kwechirwere kana kutadzisa kufambira mberi kwechirwere.
Mukuwedzera, coenzymes inogona kuwedzera kukwanisa kwekudzivirira kwekudzivirira nekuita nekusimudzira kukura kwemasero emumuviri ekuberekwa, kubudisa zvinhu zvinopesana nekuputika uye kudzvinyirira masero eT T.Nicotinamide dinucleotide oxidation state (NAD +) inonzi coenzyme inowanikwa mumasero mapenyu ose.Inoita basa rakakosha mumazana emametabolism mumasero, inotora chikamu muzviuru zvemaitiro emuviri, uye ndiyo inonyanya kukosha nhengo yeketani yekutakura erekitironi.Hydrogen donor;panguva imwecheteyo, coenzyme I inoshanda seyo yega substrate yema enzymes ane hukama mumuviri, ichibatsira kuchengetedza basa rema enzymes.
Nicotinamide mononucleotide (NMN) ndiyo inotangira musanganiswa we nicotinamide adenine dinucleotide oxidation state (NAD+), iyo inobatanidzwa mukuumbwa kweNAD mu vivo.Muna 2013, Purofesa David Sinclair weHarvard Medical School akawana kuti nezera, iyo cofactor coenzyme I (NAD +) nhanho yehupenyu hurefu hweprotein mumuviri inoramba ichidzikira, izvo zvinotungamira kudzikira kwekuita mitochondrial ye "dynamo" yesero, zvichikonzera kukwegura. , uye zvinhu zvakasiyana-siyana mumuviri.Iko kusashanda kwerudzi urwu rwebasa kunogadzirwa.Zvinoenderana neakatevedzana ezvidzidzo zvake, zviri muNAD + mumuviri wemunhu zvinodzikira nezera, zvichikonzera kukurumidza kuchembera kubva pazera re30, nemakwinya, kuzorora kwemhasuru, kuunganidza mafuta, uye zvirwere zvakaita sechirwere chemoyo, BP, sitiroko. , chirwere cheshuga uye chirwere cheAlzheimer chakawedzera njodzi.Kiyi yehupenyu hurefu ndeyekuwedzera mwero wecoenzyme I (NAD +) mumuviri, kuwedzera chiyero chesero metabolism, uye kukurudzira hunogona kuve hudiki hune simba.
API uye kugadzirira raw materials: NAD + inoshandiswa mumajekiseni ekupindwa muropa nemishonga/kudzora, kusanganisira NAD IV intravenous therapy inoshandiswa muUnited States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia nedzimwe nyika.Pharmacy yakazvigadzirira zvigadzirwa, zvakafanana nemishonga yekuAmerica, inogona kutenga zvigadzirwa zvekuzvipa yega, sekugadzirira kwechipatara cheChinese, inodzora mhando yezvigadzirwa zvega, uye inogadzirira gadziriro mumishonga.
