β-Nicotinamide adenine dinucleotide (asidhi isina mahwanda) (NAD)
NAD ikemikari yakajairika ye dehydrogenase muzvipenyu. Inobatanidzwa mukuita kwe redox muzvipenyu, uye inotakura uye inotamisa maerekitironi kuti aenderane nezvinhu zviri mukuita. Dehydrogenase ine basa guru mukuita kwemuviri wemunhu. Mamwe mafambiro ekutanga emetabolism emuviri wemunhu, akadai sekuora kweprotein, kuora kwecarbohydrate, uye kuora kwemafuta, haagone kuitwa zvakajairika pasina dehydrogenase, uye vanhu vanorasikirwa nezviratidzo zvehupenyu. Uye nekuti kusanganiswa kweNAD ne dehydrogenase kunogona kukurudzira metabolism, saka NAD chikamu chakakosha chemuviri wemunhu. Zvichienderana nekushandiswa kwechigadzirwa, chinogona kukamurwa kuita mamakisi anotevera: giredhi rebiotransformation, giredhi rediagnostic reagent, giredhi rekudya kwehutano, API uye zvinhu zvekugadzirira.
| Zita reKemikari | Nicotinamide adenine dinucleotide (asidhi yemahara) |
| Mazwi anoreva zvakafanana | β-Nicotinamide adenine dinucleotide |
| Nhamba yeCAS | 53-84-9 |
| Kurema kweMorekuru | 663.43 |
| Fomura yeMolecular | C21H27N7O14P2 |
| EINECS 号: | 200-184-4 |
| Nzvimbo yekunyunguduka | 140-142 °C (kupatsanura) |
| tembiricha yekuchengetedza. | -20°C |
| kunyungudika | H2O: 50 mg/mL |
| chimiro | Upfu |
| ruvara | Chena |
| Merck | 14,6344 |
| BRN | 3584133 |
| Kugadzikana: | Yakagadzikana. Haina kunyoroveswa. Haishande nemishonga ine simba rekuchengetedza ganda. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Chinhu Chekuyedza | Magadzirirwo |
| Chitarisiko | Upfu hwekristalline hunobva pachena kusvika pakachena |
| Kuongororwa kweUV spectral εpa 260 nm uye pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Kunyunguduka | 25mg/mL 25mg/mL mumvura |
| Zviri mukati (nekuongorora enzyme neADH pa pH 10, uchishandisa spectrophotometer, abs.340nm, pahwaro hwe anhydrous) | ≥98.0% |
| Kuyedzwa (neHPLC, pasina mvura) | 98.0~102.0% |
| Kuchena (neHPLC, %nzvimbo) | ≥99.0% |
| Mvura (neKF) | ≤3% |
Pasuru:Bhodhoro, bhegi refoiri reAruminiyamu, 25kg/Cardboard Drum, kana zvichienderana nezvinodiwa nemutengi.
Mamiriro Ekuchengetedza:Chengeta zvakavharirwa zvakasimba murima, kuti zvigare kwenguva refu. Chengeta pa2 ~ 8℃.
Giredhi reBiotransformation: Rinogona kushandiswa pakugadzira biocatalytic yemishonga inopindirana nemaAPI, kunyanya nemacatalytic enzymes, akadai se ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), glucose dehydrogenase (GDH), nezvimwewo, izvo zvinogona kushanda pamwe chete kushandura amino acid intermediates dzakasiyana-siyana nemimwe mishonga ine chekuita nazvo. Parizvino, mafekitori mazhinji emishonga emumba atanga kushandisa biological enzyme replacement, uye kudiwa kwemusika kweNAD+ kuri kukura nekukurumidza.
Rudzi rwe reagent yekuongorora: Yakasanganiswa nema enzymes akasiyana-siyana ekuongorora, sezvinhu zvakagadzirwa muzvishandiso zvekuongorora.
Chikafu chine hutano: NAD ienzyme ye dehydrogenase. Inoita basa risingatsiviwi mu glycolysis, gluconeogenesis, tricarboxylic acid cycle, uye respiratory chain, inoita basa rakakosha mukugadzirwa kwesimba, uye inobatsira mukugadzirwa kweL-dopa, iyo inova dopamine Neurotransmitters. Kunyanya mumakore achangopfuura, zvakaonekwa kuti ndiyo "injini" uye "mafuta" mukugadzirisa kukuvara kwemasero. Sekutsvagurudza, kuwedzerwa kwe coenzymes (kusanganisira NMN, NR, NAD, NADH) mu vitro kunogona kuwedzera kugona kwe antioxidant kwemasero etishu, kudzivirira apoptosis signaling, kudzoreredza mashandiro emasero akajairwa, kudzivirira kuitika kwechirwere kana kudzivirira kufambira mberi kwechirwere.
Pamusoro pezvo, ma coenzyme anogona kuwedzera kugona kwekudzivirira muviri nekukurudzira kukura kwemasero emuviri, kugadzira zvinhu zvinorwisa kuzvimba uye kudzvinyirira masero eT anodzora. Nicotinamide dinucleotide oxidation state (NAD+) i coenzyme inowanikwa mumasero ese mapenyu. Inoita basa rakakosha mumazana emaitiro emetabolism mumasero, inobata muzviuru zvezviitiko zvemuviri, uye ndiyo nhengo inonyanya kukosha yeketani yekufambisa maerekitironi. Mupi wehydrogen; panguva imwe chete, coenzyme I inoshanda sechikamu chega chega chema enzyme ane hukama mumuviri, ichibatsira kuchengetedza mashandiro ema enzyme.
Nicotinamide mononucleotide (NMN) ndiyo chinhu chinotungamira nicotinamide adenine dinucleotide oxidation state (NAD+), iyo inobatanidzwa mukugadzirwa kweNAD mumuviri. Muna 2013, Purofesa David Sinclair weHarvard Medical School akawana kuti nekukura, huwandu hwe cofactor coenzyme I (NAD+) hweprotein yehupenyu hurefu mumuviri hunoramba huchidzikira, izvo zvinotungamira kudzikira kwebasa re "dynamo" yemasero, zvichikonzera kukwegura, uye zvinhu zvakasiyana-siyana mumuviri. Kusashanda zvakanaka kwerudzi urwu rwebasa kunogadzirwa. Sekureva kweongororo dzake dzakatevedzana, huwandu hweNAD+ mumuviri wemunhu hunodzikira nekukura, zvichikonzera kukurumidza kukwegura kubva pazera remakore makumi matatu, nemakwinya, kuzorora kwetsandanyama, kuunganidzwa kwemafuta, uye zvirwere zvakaita sechirwere chemwoyo, BP, sitiroko, chirwere cheshuga nechirwere cheAlzheimer hwakawedzera njodzi. Chinhu chikuru chekurarama kwenguva refu ndechekuwedzera huwandu hwe coenzyme I (NAD+) mumuviri, kuwedzera mwero we metabolism yemasero, uye kukurudzira simba rehudiki.
API uye kugadzirira zvinhu zvekushandisa: NAD+ inoshandiswa mumajekiseni ekurapa/kudzora kupindwa muropa nezvinodhaka, kusanganisira NAD IV intravenous therapy inoitirwa muUnited States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia nedzimwe nyika. Zvigadzirwa zve pharmacy, zvakafanana nema pharmacy ekuAmerica, zvinogona kutenga zvinhu zvekushandisa zvega, kungofanana nekugadzirira zvipatara zvekuChina, inodzora mhando yezvinhu zvekushandisa zvega, uye inogadzirira mishonga.
