Amine Dehydrogenase (AmDH)
Tsanangudzo Pfupi
Nezve Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme inogona kukonzera ammoniation yeboka recarbonyl uye kuidzikisa kuva amino boka.Iyo coenzyme NADH inotsamira enzyme, uye NADH inoshanda seye hydrogen transmitter.Kune 4 mhando dzeAmDH enzyme zvigadzirwa (Nhamba seES-AmDH101～ES-AmDH104) yakagadzirwa neSyncoZymes, inogona kushandiswa mu regioselective kana stereoelective reductive amination yealdehydes nemaketone.
Catalytic reaction type:
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★ High substrate chaiyo.
★ Strong chiral selectivity.
★ Kutendeuka kwepamusoro.
★ Zvishoma ne-zvigadzirwa.
★ Mild reaction conditions.
★ Kuchengetedza zvakatipoteredza.
➢ Kazhinji, maitiro ekuita anofanira kusanganisira substrate, buffer solution, enzyme, coenzyme uye coenzyme regeneration system (eg glucose uye glucose dehydrogenase).
➢ AmDH inofanirwa kuwedzerwa kwekupedzisira mukuita system, mushure mekunge pH uye tembiricha zvagadziriswa kune mamiriro ekuita.
Muenzaniso 1(Synthesis yeinowirirana chiral amines nekuderedza amination yealkyl aryl ketones)(1):
Chengeta makore maviri pasi -20 ℃.
Usambofa wakasangana nemamiriro akanyanya akadai se: tembiricha yakakwira, yakakwira / yakaderera pH uye yakakwira concentration organic solvent.
1. Kong W, Liu Y, Huang C, nevamwe.Angewandte Chemie International Edition, 2022: e202202264.
