Amine Dehydrogenase (AmDH)
Tsananguro pfupi:
Nezve Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme inogona kukonzera ammoniation yeboka recarbonyl uye kuideredza kuita amino group. Ienzyme inoenderana necoenzyme NADH, uye NADH inoshanda semutakuri wehydrogen. Kune mhando ina dzezvigadzirwa zveAmDH enzyme (Nhamba seES-AmDH101～ES-AmDH104) yakagadzirwa neSyncoZymes, iyo inogona kushandiswa mu regioselective kana stereoselective reductive amination yealdehydes nemaketones.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
★ Hunhu hwepamusoro hwe substrate.
★ Kusarudza kwakasimba kwerudo rwechikara.
★ Kuchinja kwakanyanya.
★ Zvibereko zvishoma.
★ Mamiriro ekuita zvinhu zvisina kusimba.
★ Inochengetedza zvakatipoteredza.
➢ Kazhinji, nzira yekugadzirira inofanira kusanganisira substrate, buffer solution, enzyme, coenzyme uye coenzyme regeneration system (semuenzaniso glucose neglucose dehydrogenase).
➢ AmDH inofanira kuwedzerwa pakupedzisira mu reaction system, mushure mekunge pH netembiricha zvagadziriswa kuti zvienderane nemamiriro e reaction.
Muenzaniso 1 (Kugadzirwa kweamines dzechiral dzinoenderana nekuderedza alkyl aryl ketones)(1):
Chengeta kwemakore maviri pasi pe -20℃.
Usambosangana nemamiriro ezvinhu akaipisisa akadai se: tembiricha yakakwira, pH yakakwira/yakaderera uye organic solvent yakakwira.
1. Kong W, Liu Y, Huang C, nevamwe. Angewandte Chemie International Edition, 2022: e202202264.
