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Imine reductase (IRED)
About Imine reductase
ES-IRED: Kirasi yema enzymes anokonzera kuderedzwa kweC = N bond kuCN bond.Iyo ndeye redox enzyme, ine coenzyme NADPH yekutakura hydrogen.Zvinoenderana nezvinodiwa zvechiral zvezvigadzirwa, zvinogona kukamurwa kuita R-IRED uye S-IRED.Syncozymes yakagadzirwa 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), iyo inogona kushandiswa zvakanyanya mu regioselective uye stereoelective kuderedza imines kugadzirira chiral amines.
Catalytic reaction type:
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Nitrile reductase (NRED)
Nezve Nitrile reductase
Kune mhando nhatu dzeNRED enzyme chigadzirwa (Nhamba seES-NRED101~ ES-NRED103) yakagadzirwa neSyncoZymes.NRED inogona kukonzera kudzikiswa kweboka re nitrile kune amine.Mukuita catalysis, NADPH inodiwa semutakuri wehydrogen.
Nitrile reductasecatalytic reaction type
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Phenylalanine dehydrogenase (PDH)
Pamusoro pePhenylalanine dehydrogenase
ES-PDH: Kirasi ye oxidoreductase.Kuita kwakanaka kunogona kukonzera oxidative deamination yeL phenylalanine munyu pamberi peNAD kuti ibudise phenylpyruvate munyu, uye reverse reaction inogona kukonzera kuumbwa kweinofanana amino acid munyu kubva phenylpyruvate munyu.Syncozymes yakagadzirwa 8 zvinhu zve phenylalanine dehydrogenase (inoverengwa ES-PDH-101~ES-PDH-108).ES-PDH inogona kushandiswa kugadzira phenylalanine munyu kana inowirirana amino acid munyu kubva phenylpyruvic acid munyu kana zvinobva.
Catalytic reaction type:
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Leucine Dehydrogenase (LeuDH)
Nezve Leucine dehydrogenase
Kune rudzi rumwe rweLeuDH enzyme chigadzirwa (Nhamba seES-LeuDH-101) yakagadzirwa neSyncoZymes.LeuDH inogona kukonzera reductive ammoniation ye4-methylbutanoic acid (munyu) kuL-leucine kana kuti oxidation ye leucine kune 4-methylbutanoic acid.ES-LeuDH inogonawo kukonzera reductive amination ye α-keto acids ine chimiro chakafanana kugadzirira zvinoenderana neamino acid derivatives.Mukuita catalysis, NADH inodiwa sehydrogen transporter.
Leucine dehydrogenasecatalytic reaction type
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Threonine deaminase (TDA)
Pamusoro peThreonine deaminase
ES-TDA (Threonine deaminase): pyridoxal phosphate protein inokonzera deamination yethreonine kuti ibudise 2-ketobutyric acid uye ammonia.Pyridoxal 5-phosphate inodiwa se coenzyme mu catalytic system.Kune chete mhando imwe chete yeTDA enzyme chigadzirwa (Nhamba seES-TDA) yakagadziridzwa neSyncoZymes, inogona kushandiswa kugadzira 2-ketobutyric asidhi kana zvinobva zvayo kubva kuthreonine.
Catalytic reaction type:
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Amine Dehydrogenase (AmDH)
Nezve Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme inogona kukonzera ammoniation yeboka recarbonyl uye kuidzikisa kuva amino boka.Iyo coenzyme NADH inotsamira enzyme, uye NADH inoshanda seye hydrogen transmitter.Kune 4 mhando dzeAmDH enzyme zvigadzirwa (Nhamba seES-AmDH101～ES-AmDH104) yakagadzirwa neSyncoZymes, inogona kushandiswa mu regioselective kana stereoelective reductive amination yealdehydes nemaketone.
Catalytic reaction type:
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Nucloside phosphoryalse (NP)
Nezve nucleoside phosphoryalse
Kune matatu marudzi eNP enzyme zvigadzirwa (Nhamba seES-NP-101~ ES-NP-103) yakagadzirwa neSyncoZymes.ES-NP-101 inonzi purine nucleoside phosphorylase, ES-NP-102 uye ES-NP-103 ndeye pyrimidine nucleoside phosphorylase.Nucleosidephosphorylase inogona kuparadza nucleosides kuita mabhesi uye pentose phosphate.Nucleoside phosphorylase inogona kukamurwa kuita purine nucleoside phosphorylase uye pyrimidine nucleoside phosphorylase zvinoenderana nezvinodiwa zvenyucleoside base.Purine nucleoside phosphorylase inogona metabolize adenosine kuadenine, inosine kune hypoxanthine, guanosine kuguanine, uye kugadzira ribose phosphate panguva imwe chete.Pyrimidine nucleoside phosphorylase inogona kuisa uridine kune uracil uye kuburitsa ribose phosphate.
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Hydroaminase (HAM)
Pamusoro peHydroaminase
Kune marudzi maviri echigadzirwa cheHAM enzyme (Nhamba seES-HAM-101~ ES-HAM-102) yakagadzirwa neSyncoZymes.HAM inogona kukonzeresa ammoniation yeanoic acid kana zvinobva pairi kugadzira chiral amino acids.HAM inogona kushandiswa kugadzira chiral amino acids (kana chiral amines) kubva kuenoic acids (kana alkenes).Ammonia donor, senge ammonia mvura kana ammonium munyu, inofanirwa.
Hydroaminase catalytic reaction type
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Immobilized CALB
CALB
Recombinant Lipase B kubva kuCandida antarctica (CALB) inogadzirwa nekuvirisa kwakanyudzwa mumvura ine genetically modified Pichia pastoris.
CALB inogona kushandiswa muchikamu chemvura kana organic phase catalytic esterification, esterolysis, transesterification, mhete yekuvhura polyester synthesis, aminolysis, hydrolysis yeamides, acylation yemamines uye kuwedzera maitiro.
CALB ine high chiral selectivity uye sarudzo yekusarudza, saka inogona kushandiswa zvakanyanya mukugadzira mafuta, chikafu, mishonga, cosmetic uye mamwe maindasitiri emakemikari.
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NADH oxidase (NOX)
Nezve NADH oxidase
ES-NOX (NADH oxidase): NOX inokonzera oxidation yeNADH kuenda kuNAD +, uye ndeye oxidoreductase.Mukuita oxidation, O2 inodiwa seoxidant, uye yakaderedzwa kusvika H2O kana H2O2.Kune marudzi mana emhando dzeNOX enzyme zvigadzirwa (ES-NOX-101~ES-NOX-104) yakagadziridzwa nekambani yedu, iyo inogona kushandiswa kugadziridza oxidation ye coenzyme NAD +.
Catalytic reaction type:
or
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Phenylalanine ammonia lyase (PAL)
Pamusoro pePhenylalanine ammonia lyase
ES-PAL: Kirasi yema enzymes anokonzera deamination yakananga yeL-phenylalanine kune transcinnamic acid.Syncozymes yakagadzira gumi zvinhu zve phenylalanine ammonia lyase (inoverengerwa ES-PAL-101~ES-PAL-110), iyo inogona kushandiswa mu deamination kana kudzosera reverse reaction ye phenylalanine nezvayakabva.
Catalytic reaction type:
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Catalase (CAT)
About Catalase
ES-CAT (Catalase): inokonzera kuparara kweH2O2 muokisijeni nemvura.Iyo inonyanya kuvepo mumitochondria, endoplasmic reticulum, chiropa chemhuka uye masero matsvuku eropa, kunyanya muchiropa pakusangana kwakanyanya, inopa antioxidant kudzivirira basa remuviri.Mu biocatalysis, inonyanya kushandiswa kubvisa maitiro ne-product hydrogen peroxide uye kuderedza inhibition uye kusashanda kwe enzyme ne hydrogen peroxide.Kune chete mhando imwe chete yeCAT enzyme zvigadzirwa zvakagadzirwa neSyncoZymes (Nhamba seES-CAT).
Catalytic reaction type:
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