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Imine reductase (IRED)
Nezve Imine reductase
ES-IRED: Rudzi rwema enzymes anokonzera kudzikiswa kweC=N bond kuCN bond. Ndeye redox enzyme, ine coenzyme NADPH yekufambisa hydrogen. Zvichienderana nezvinodiwa ne chiral zvezvigadzirwa, zvinogona kukamurwa kuita R-IRED naS-IRED. Syncozymes yakagadzira gumi neshanu imine reductases (numbIRED ES-IRED-101-ES-IRED-115), iyo inogona kushandiswa zvakanyanya mu regioselective uye stereoselective reduction ye imines kugadzira chiral amines.
Rudzi rwekuita kweCatalytic:
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Nitrile reductase (NRED)
Nezve Nitrile reductase
Kune mhando nhatu dzechigadzirwa cheNRED enzyme (Nhamba seES-NRED101~ ES-NRED103) chakagadzirwa neSyncoZymes. NRED inogona kukonzera kudzikira kweboka re nitrile kuita amine. Mukuita kwe catalysis, NADPH inodiwa semutakuri wehydrogen.
Nitrile reductasecatalytic reaction type
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Leucine Dehydrogenase (LeuDH)
Nezve Leucine dehydrogenase
Kune rudzi rumwe chete rweLeuDH enzyme product (Nhamba seES-LeuDH-101) yakagadzirwa neSyncoZymes. LeuDH inogona kukonzera ammoniation ye4-methylbutanoic acid (munyu) kuL-leucine kana oxidation yeleucine ku4-methylbutanoic acid. ES-LeuDH inogona zvakare kukonzera kuderedza kuderedza kweα-keto acids ine chimiro chakafanana kugadzira amino acid derivatives inoenderana. Mukuita kwe catalysis, NADH inodiwa semutakuri wehydrogen.
Leucine dehydrogenasecatalytic reaction rudzi
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Threonine deaminase (TDA)
Nezve Threonine deaminase
ES-TDA (Threonine deaminase): puroteni yepyridoxal phosphate inokonzeresa kubviswa kwethreonine kuti igadzire 2-ketobutyric acid uye ammonia. Pyridoxal 5-phosphate inodiwa se coenzyme mu catalytic system. Kune mhando imwe chete yechigadzirwa cheTDA enzyme (Nhamba seES-TDA) yakagadzirwa neSyncoZymes, iyo inogona kushandiswa kugadzira 2-ketobutyric acid kana zvinobva mairi kubva ku threonine.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Amine Dehydrogenase (AmDH)
Nezve Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme inogona kukonzera ammoniation yeboka recarbonyl uye kuideredza kuita amino group. Ienzyme inoenderana necoenzyme NADH, uye NADH inoshanda semutakuri wehydrogen. Kune mhando ina dzezvigadzirwa zveAmDH enzyme (Nhamba seES-AmDH101～ES-AmDH104) yakagadzirwa neSyncoZymes, iyo inogona kushandiswa mu regioselective kana stereoselective reductive amination yealdehydes nemaketones.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Nucloside phosphorylse (NP)
Nezve nucleoside phosphorylse
Kune mhando nhatu dzezvigadzirwa zve NP enzyme (Nhamba se ES-NP-101~ ES-NP-103) zvakagadzirwa neSyncoZymes. ES-NP-101 ipurine nucleoside phosphorylase, ES-NP-102 uye ES-NP-103 ipyrimidine nucleoside phosphorylase. Nucleosidephosphorylase inogona kuputsa nucleosides kuita mabhesi uye pentose phosphate. Nucleoside phosphorylase inogona kukamurwa kuita purine nucleoside phosphorylase uye pyrimidine nucleoside phosphorylase zvichienderana nezvinodiwa ne nucleoside bases. Purine nucleoside phosphorylase inogona kusanganisa adenosine ne adenine, inosine ne hypoxanthine, guanosine ne guanine, uye kugadzira ribose phosphate panguva imwe chete. Pyrimidine nucleoside phosphorylase inogona kusanganisa uridine ne uracil uye kugadzira ribose phosphate.
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Hydroaminase (HAM)
Nezve Hydroaminase
Kune mhando mbiri dzechinhu chinogadzirwa neHAM enzyme (Nhamba seES-HAM-101~ ES-HAM-102) chakagadzirwa neSyncoZymes. HAM inogona kukonzera ammonia yeenoic acid kana zvinobva mairi kuti igadzire chiral amino acids. HAM inogona kushandiswa kugadzira chiral amino acids (kana chiral amines) kubva kuenoic acids (kana alkenes). Ammonia donor, senge ammonia water kana ammonium salt, inodiwa.
Hydroaminase catalytic reaction rudzi
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CALB Isina Kufamba
CALB
Recombinant Lipase B inobva kuCandida antarctica (CALB) inogadzirwa nekuvirisa mumvura nePichia pastoris yakagadziriswa majini.
CALB inogona kushandiswa muchikamu chemvura kana chikamu cheorganic catalytic esterification, esterosis, transesterification, ring opening polyester synthesis, aminolysis, hydrolysis yeamides, acylation yeamines uye addition reaction.
CALB ine chiral selectivity yakanyanya uye chinzvimbo selectivity, saka inogona kushandiswa zvakanyanya mukugadzira mafuta, chikafu, mishonga, cosmetic uye mamwe maindasitiri emakemikari.
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NADH oxidase (NOX)
Nezve NADH oxidase
ES-NOX (NADH oxidase): NOX inokonzeresa oxidation yeNADH kuenda kuNAD+, uye ndeye oxidoreductase. Mukuita oxidation, O2 inodiwa se oxidant, uye inoderedzwa kusvika kuH2O kana H2O2. Kune mhando ina dze NOX enzyme products (ES-NOX-101~ES-NOX-104) yakagadzirwa nekambani yedu, iyo inogona kushandiswa pakugadzirisa oxidation ye coenzyme NAD+.
Rudzi rwekuita kweCatalytic:
or
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Phenylalanine ammonia lyase (PAL)
Nezve Phenylalanine ammonia lyase
ES-PAL: Rudzi rwema enzymes anokonzera kubviswa kweL-phenylalanine zvakananga kuita transcinnamic acid. Syncozymes yakagadzira zvinhu gumi zvephenylalanine ammonia lyase (yakaverengerwa ES-PAL-101~ES-PAL-110), izvo zvinogona kushandiswa mukubvisa kana kudzoreredza reverse response yephenylalanine nezvimwe zvinobva mairi.
Rudzi rwekuita kweCatalytic:
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Catalase (CAT)
NezveCatalase
ES-CAT (Catalase): inokonzeresa kuora kweH2O2 kuita okisijeni nemvura. Inonyanya kuwanikwa mumitochondria, endoplasmic reticulum, chiropa chemhuka nemasero matsvuku eropa, kunyanya muchiropa chine huwandu hwakawanda, ichipa basa rekudzivirira muviri kubva pakukuvadza mabhakitiriya. Mubiocatalysis, inonyanya kushandiswa kubvisa reaction by-product hydrogen peroxide uye kuderedza kudziviswa uye kushaikwa kweenzyme nehydrogen peroxide. Kune mhando imwe chete yezvigadzirwa zveCAT enzyme zvakagadzirwa neSyncoZymes (Nhamba seES-CAT).
Rudzi rwekuita kweCatalytic:
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Lysine oxidase (LO)
Nezve Lysine oxidase
ES-LO (Lysine oxidase): inokonzeresa oxidation yeL-lysine kuita 6-amino-2-oxohexanoic acid (kana lactone yayo). Kune mhando imwe chete yechigadzirwa cheLO enzyme (Nhamba seES-LO) yakagadzirwa neSyncoZymes.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
