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MaOxynitrilases (HNL)
Nezve oxynitrilases
ES-HNLs: Iyi enzyme yekirasi inosanganisa kuwedzera kweHCN mu aldehydes (ketones) kuti iwane R kana S type cyanide alcohols, iyo inogona kushandurwa nyore nyore kuita mhando dzakawanda dzemishonga kana mishonga inopindirana kuburikidza nenzira yemakemikari.
Kune mhando makumi maviri nemapfumbamwe dzezvigadzirwa zve oxynitrilase (Nhamba seES-HNL-101～ES-HNL-129) zvakagadzirwa neSyncoZymes. SZ-HNL chishandiso chinobatsira pakugadzira (R)-cyanohydrins kana (S)-cyanohydrins kubva mumhando dzakasiyana dzearomatic, aliphatic uye heterocyclic aldehydes kana kunyange ketones.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Nitro reductase (NTR)
Nezve nitro reductase
ES-NTRs: Ndiwo ma flavoenzymes anokonzera kudzikiswa kweNAD(P)H kwema nitro groups pa nitroaromatic ne nitroheterocyclic compounds kuita hydroxylamino uye/kana amino derivatives. Anoshandiswa zvakanyanya mukugadzirwa kwe aromatic hydroxylamine ne aromatic amine, kurapwa ne tumor, kuona biological uye kuparadza tsvina yezvakatipoteredza. Kune mhando gumi nembiri dzeNitro reductase (NTR) products (Nhamba seES-NTR-101~ES-NTR-112) yakagadzirwa neSyncoZymes.
Nharembozha/Wechat/WhatsApp: +86-13681683526
Tsamba yemagetsi:lchen@syncozymes.com
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Aldolase (DERA)
ES-DERA: Inogona kumutsa zvinobudirira kuwedzera ma ketone evanopa kune ma receptor aldehydes. Uyezve, mhinduro yacho inogona kuitwa mumvura ine pH isina kusimba pasina matanho akakosha ekudzivirira. Ndee class I aldolase, iyo inoumba Shiff base mu catalytic process. Substrate iyi yakabatana ne amino group yenzvimbo inoshanda kuti itange kutyoka uye kuumbwa kwechisungo. Musiyano uripo pakati peDERA nedzimwe aldolases ndewekuti substrates dzavanomutsa i aldehydes uye dzinogona kunyura mu continuous aldehydes condensation.
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Tsamba yemagetsi:lchen@syncozymes.com
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Cytochrome P450 monooxygenase (CYP)
NezveCYP
ES-CYPs: Rudzi rwema enzymes e redox ane mercaptan-heme senzvimbo inoshanda yekufambisa okisijeni. Aya ndiwo ma terminal oxygenases uye anoda heme kuti aite kuti okisijeni ishande.
Cytochrome P450 monooxygenase inokonzeresa oxidation, epoxidation uye hydroxylation yealkyl, hydroxylation uye oxidation yeammonia, oxidation yesarufa, dealkylation (oxygen, sarufa, ammonia), oxidative dehydrogenation, deamination uye dehalogenation.
Kune mhando sere dzezvigadzirwa zve cytochrome P450 monooxygenase (Nhamba seES-CYP-101～ES-CYP-108) zvakagadzirwa neSyncoZymes.Nharembozha/Wechat/WhatsApp: +86-13681683526
Tsamba yemagetsi:lchen@syncozymes.com
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Doro rinopisa (AOX)
Nezve alcohol oxidase
ES-AOXs: Ma enzyme aya anokwanisa kukonzera oxidation yemafuta alcohols kana aryl-alcohols kuti igadzire aldehydes. Anoshandisa molecular oxygen asi haadi cofactor yakawedzerwa kunze, uye hydrogen peroxide inogadzirwa.
Kune mhando nhanhatu dzezvigadzirwa zvealcohol oxidases (Nhamba seES-AOX-101~ES-AOX-106) zvakagadzirwa neSyncoZymes. ES-AOX101 neES-AOX102 dzinoda substrates dzealcohol dzakagadzirwa nealiphatic, ES-AOX103~ ES-AOX105 dzinoda substrates dzealcohol dzine aromatic, uye ES-AOX106 icholesterol oxidase. SZ-AOX chishandiso chinobatsira pakugadzira oxidation yemafuta ane alcohols kana aryl-alcohols kuti igadzire aldehydes.
Rudzi rwekuita kweCatalytic:
Nharembozha/Wechat/WhatsApp: +86-13681683526
Tsamba yemagetsi:lchen@syncozymes.com
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D-Amino acid dehydrogenase (D-AADH)
Nezve D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): enzyme inogona kuderedza 2-keto acid kuita D-amino acid inoenderana. Zvinodiwa neNADP(H) uye inorganic ammonia donor (senge ammonia kana ammonium ion). Kune mhando gumi nenomwe dzeD-amino acid dehydrogenases (Nhamba seES-DAADH-101~ ES-DAADH-117) yakagadzirwa neSyncoZymes.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Esterase neLipase (PLE neCALB)
Nezve Esterase & Lipase
ES-PLEs: Rudzi rwemahydrolases anokonzera kuumbwa nekutyoka kwema ester bonds. Anogona kutora chikamu mumhando dzakasiyana dzemaitiro emakemikari, akadai se esterification, transesterification uye hydrolysis. Anoshandiswa zvakanyanya muminda yakawanda yakadai sekugadzira chikafu, indasitiri yemakemikari, biomedicine, chiral medicine uye kurapa nharaunda.
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Tsamba yemagetsi:lchen@syncozymes.com
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Epoxide hydrolase (EH)
Nezve epoxide hydrolase
EH iether hydrolase inokonzeresa stereoselective hydrolysis ye racemic epoxides kuti igadzire 1, 2-diol uye optically active epoxides, iyo inogona kushandiswa pakugadzirisa chiral ye epoxides kana kugadzira chiral diols. Inoshandiswa zvakanyanya mukurapa nedzimwe nzvimbo. Kune mhando nhatu dze epoxide hydrolases zvigadzirwa (Nhamba seES-EH-101～ES-EH-103) yakagadzirwa neSyncoZymes. ES-EH chishandiso chinobatsira che catalyst synthesis ye chiral alcohols kuburikidza ne stereoselective hydrolysis ye aliphatic ne aromatic epoxides.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Formate dehydrogenase (FDH)
Nezve Formate dehydrogenase
ES-FDH (Formate dehydrogenase): FDH inokonzera kubviswa kwehydrogenation yeammonium formate kuti igadzire carbon dioxide neammonia, uye inoderedza NAD kuita NADH neNAD se electron receptor. FDH inowanzoshandiswa pakugadzirwazve kwe coenzyme NADH. Kune mhando ina dzeFDH enzyme products (ES-FDH-101~ES-FDH-104) yakagadzirwa neSyncoZymes, pakati payo ES-FDH102 ine basa guru uye ndiyo FDH inokurudzirwa zvikuru.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Glucose dehydrogenase (GDH)
Nezve Glucose dehydrogenase
ES-GDH (Glucose dehydrogenase): GDH inokonzeresa kubviswa kweglucose kuti igadzire gluconic acid (lactone), uye inoderedza NAD(P)+ kuita NAD(P)H, neNAD(P)+ se electron receptor. GDH inowanzoshandiswa pakugadzirisa coenzyme NAD(P)H muminda ye biocatalysis pamwe chete nedzimwe enzyme huru. Kune mhando gumi dzezvigadzirwa zve GDH enzyme (ES-GDH-101~ES-GDH-110) zvakagadzirwa neSyncoZymes, pakati payo ES-GDH110 ine basa repamusoro uye ndiyo GDH inokurudzirwa zvikuru.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Monoamine oxidase (MAO)
Nezve Monoamine oxidase
ES-MAO (Monoamine oxidase): MAO inokonzeresa kucheneswa kweoxidative kwemamonoamines kuti igadzire hydrogen peroxide, ammonia uye aldehydes dzinoenderana. Mukuita kwe catalytic, okisijeni inodiwa se oxidant. Kune mhando nhanhatu dzeMAO enzyme products (Nhamba seES-MAO-101～ES-MAO-106) yakagadzirwa neSyncoZymes, iyo inogona kushandiswa mucheneswa kweoxidative kwemamonoamine compounds.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Lactate Dehydrogenase (LDH)
Nezve Lactate dehydrogenase
Kune mhando imwe chete yechinhu chinogadzirwa neenzyme yeLDH (Nhamba seES-LDH) yakagadzirwa neSyncoZymes. LDH inogona kukonzera kudzikira kwepyruvate kuita L-lactic acid, kana kudzikira kwemamwe ma α-keto acids akafanana. Mukuita kwe catalysis, NADH inodiwa semutakuri wehydrogen.
Lactate dehydrogenasecatalytic reaction mhando
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Tsamba yemagetsi:lchen@syncozymes.com
