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D-Amino acid dehydrogenase (D-AADH)
Nezve D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): enzyme inogona kuderedza 2-keto acid kuita D-amino acid inoenderana. Zvinodiwa neNADP(H) uye inorganic ammonia donor (senge ammonia kana ammonium ion). Kune mhando gumi nenomwe dzeD-amino acid dehydrogenases (Nhamba seES-DAADH-101~ ES-DAADH-117) yakagadzirwa neSyncoZymes.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Esterase neLipase (PLE neCALB)
Nezve Esterase & Lipase
ES-PLEs: Rudzi rwemahydrolases anokonzera kuumbwa nekutyoka kwema ester bonds. Anogona kutora chikamu mumhando dzakasiyana dzemaitiro emakemikari, akadai se esterification, transesterification uye hydrolysis. Anoshandiswa zvakanyanya muminda yakawanda yakadai sekugadzira chikafu, indasitiri yemakemikari, biomedicine, chiral medicine uye kurapa nharaunda.
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Tsamba yemagetsi:lchen@syncozymes.com
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Epoxide hydrolase (EH)
Nezve epoxide hydrolase
EH iether hydrolase inokonzeresa stereoselective hydrolysis ye racemic epoxides kuti igadzire 1, 2-diol uye optically active epoxides, iyo inogona kushandiswa pakugadzirisa chiral ye epoxides kana kugadzira chiral diols. Inoshandiswa zvakanyanya mukurapa nedzimwe nzvimbo. Kune mhando nhatu dze epoxide hydrolases zvigadzirwa (Nhamba seES-EH-101～ES-EH-103) yakagadzirwa neSyncoZymes. ES-EH chishandiso chinobatsira che catalyst synthesis ye chiral alcohols kuburikidza ne stereoselective hydrolysis ye aliphatic ne aromatic epoxides.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Formate dehydrogenase (FDH)
Nezve Formate dehydrogenase
ES-FDH (Formate dehydrogenase): FDH inokonzera kubviswa kwehydrogenation yeammonium formate kuti igadzire carbon dioxide neammonia, uye inoderedza NAD kuita NADH neNAD se electron receptor. FDH inowanzoshandiswa pakugadzirwazve kwe coenzyme NADH. Kune mhando ina dzeFDH enzyme products (ES-FDH-101~ES-FDH-104) yakagadzirwa neSyncoZymes, pakati payo ES-FDH102 ine basa guru uye ndiyo FDH inokurudzirwa zvikuru.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Glucose dehydrogenase (GDH)
Nezve Glucose dehydrogenase
ES-GDH (Glucose dehydrogenase): GDH inokonzeresa kubviswa kweglucose kuti igadzire gluconic acid (lactone), uye inoderedza NAD(P)+ kuita NAD(P)H, neNAD(P)+ se electron receptor. GDH inowanzoshandiswa pakugadzirisa coenzyme NAD(P)H muminda ye biocatalysis pamwe chete nedzimwe enzyme huru. Kune mhando gumi dzezvigadzirwa zve GDH enzyme (ES-GDH-101~ES-GDH-110) zvakagadzirwa neSyncoZymes, pakati payo ES-GDH110 ine basa repamusoro uye ndiyo GDH inokurudzirwa zvikuru.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Monoamine oxidase (MAO)
Nezve Monoamine oxidase
ES-MAO (Monoamine oxidase): MAO inokonzeresa kucheneswa kweoxidative kwemamonoamines kuti igadzire hydrogen peroxide, ammonia uye aldehydes dzinoenderana. Mukuita kwe catalytic, okisijeni inodiwa se oxidant. Kune mhando nhanhatu dzeMAO enzyme products (Nhamba seES-MAO-101～ES-MAO-106) yakagadzirwa neSyncoZymes, iyo inogona kushandiswa mucheneswa kweoxidative kwemamonoamine compounds.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Lactate Dehydrogenase (LDH)
Nezve Lactate dehydrogenase
Kune mhando imwe chete yechinhu chinogadzirwa neenzyme yeLDH (Nhamba seES-LDH) yakagadzirwa neSyncoZymes. LDH inogona kukonzera kudzikira kwepyruvate kuita L-lactic acid, kana kudzikira kwemamwe ma α-keto acids akafanana. Mukuita kwe catalysis, NADH inodiwa semutakuri wehydrogen.
Lactate dehydrogenasecatalytic reaction mhando
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Imine reductase (IRED)
Nezve Imine reductase
ES-IRED: Rudzi rwema enzymes anokonzera kudzikiswa kweC=N bond kuCN bond. Ndeye redox enzyme, ine coenzyme NADPH yekufambisa hydrogen. Zvichienderana nezvinodiwa ne chiral zvezvigadzirwa, zvinogona kukamurwa kuita R-IRED naS-IRED. Syncozymes yakagadzira gumi neshanu imine reductases (numbIRED ES-IRED-101-ES-IRED-115), iyo inogona kushandiswa zvakanyanya mu regioselective uye stereoselective reduction ye imines kugadzira chiral amines.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Nitrile reductase (NRED)
Nezve Nitrile reductase
Kune mhando nhatu dzechigadzirwa cheNRED enzyme (Nhamba seES-NRED101~ ES-NRED103) chakagadzirwa neSyncoZymes. NRED inogona kukonzera kudzikira kweboka re nitrile kuita amine. Mukuita kwe catalysis, NADPH inodiwa semutakuri wehydrogen.
Nitrile reductasecatalytic reaction type
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Leucine Dehydrogenase (LeuDH)
Nezve Leucine dehydrogenase
Kune rudzi rumwe chete rweLeuDH enzyme product (Nhamba seES-LeuDH-101) yakagadzirwa neSyncoZymes. LeuDH inogona kukonzera ammoniation ye4-methylbutanoic acid (munyu) kuL-leucine kana oxidation yeleucine ku4-methylbutanoic acid. ES-LeuDH inogona zvakare kukonzera kuderedza kuderedza kweα-keto acids ine chimiro chakafanana kugadzira amino acid derivatives inoenderana. Mukuita kwe catalysis, NADH inodiwa semutakuri wehydrogen.
Leucine dehydrogenasecatalytic reaction rudzi
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Threonine deaminase (TDA)
Nezve Threonine deaminase
ES-TDA (Threonine deaminase): puroteni yepyridoxal phosphate inokonzeresa kubviswa kwethreonine kuti igadzire 2-ketobutyric acid uye ammonia. Pyridoxal 5-phosphate inodiwa se coenzyme mu catalytic system. Kune mhando imwe chete yechigadzirwa cheTDA enzyme (Nhamba seES-TDA) yakagadzirwa neSyncoZymes, iyo inogona kushandiswa kugadzira 2-ketobutyric acid kana zvinobva mairi kubva ku threonine.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
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Amine Dehydrogenase (AmDH)
Nezve Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme inogona kukonzera ammoniation yeboka recarbonyl uye kuideredza kuita amino group. Ienzyme inoenderana necoenzyme NADH, uye NADH inoshanda semutakuri wehydrogen. Kune mhando ina dzezvigadzirwa zveAmDH enzyme (Nhamba seES-AmDH101～ES-AmDH104) yakagadzirwa neSyncoZymes, iyo inogona kushandiswa mu regioselective kana stereoselective reductive amination yealdehydes nemaketones.
Rudzi rwekuita kweCatalytic:
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Tsamba yemagetsi:lchen@syncozymes.com
