Epoxide hydrolase (EH)
Tsanangudzo Pfupi
Nezve epoxide hydrolase
EH is ether hydrolase iyo inokonzera stereoelective hydrolysis ye racemic epoxides kuti ibudise 1, 2-diol uye optical active epoxides, inogona kushandiswa kugadzirisa chiral epoxides kana kugadzirira chiral diols.Vanoshandiswa zvakanyanya mukurapa uye mune mamwe minda.Kune marudzi matatu eepoxide hydrolases zvigadzirwa (Nhamba seES-EH-101～ES-EH-103) yakagadzirwa neSyncoZymes.ES-EH chishandiso chinoshanda chekugadzirisa kuumbwa kwechiral alcohols kuburikidza nestereoelective hydrolysis yealiphatic uye inonhuhwirira epoxides.
Catalytic reaction type:
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| Enzymes | Product Code | Tsanangudzo |
| Enzyme Powder | ES-EH-101~ ES-EH-103 | seti ye3 Epoxide Hydrolases, 50 mg imwe neimwe 3 zvinhu * 50mg / chinhu, kana humwe huwandu |
| Screening Kit (SynKit) | ES-EH-300 | seti ye3 Epoxide Hydrolases, 1 mg imwe neimwe 3 zvinhu * 1mg / chinhu |
★ High substrate chaiyo.
★ Strong chiral selectivity.
★ Kutendeuka kwepamusoro.
★ Zvishoma ne-zvigadzirwa.
★ Mild reaction conditions.
★ Kuchengetedza zvakatipoteredza.
➢ Kazhinji, maitiro ekuita anofanira kusanganisira substrate, buffer solution (optimum reaction pH) uye ES-EH.
➢ Mhando dzose dzeES-EH dzinoenderana nemhando dzakasiyana-siyana dzekuita dzinofanirwa kudzidzwa yega.
➢ High concentration yeSubstrate kana chigadzirwa chine chinogona kutadzisa kuita kweES-EH.Nekudaro, iyo inhibition inogona kudzikiswa nebatch kuwedzera kwe substrate.
Muenzaniso 1(1):
Chengeta makore maviri pasi -20 ℃.
Usambofa wakasangana nemamiriro akanyanya akadai se: tembiricha yakakwira, yakakwira / yakaderera pH uye yakakwira concentration organic solvent.
1. Kim YH, Lee I, Choi SH, e tal.J Mol Catal B-Enzym, 2013, 89: 48-51.
