Imine reductase (IRED)
Tsananguro pfupi:
Nezve Imine reductase
ES-IRED: Rudzi rwema enzymes anokonzera kudzikiswa kweC=N bond kuCN bond. Ndeye redox enzyme, ine coenzyme NADPH yekufambisa hydrogen. Zvichienderana nezvinodiwa ne chiral zvezvigadzirwa, zvinogona kukamurwa kuita R-IRED naS-IRED. Syncozymes yakagadzira gumi neshanu imine reductases (numbIRED ES-IRED-101-ES-IRED-115), iyo inogona kushandiswa zvakanyanya mu regioselective uye stereoselective reduction ye imines kugadzira chiral amines.
Rudzi rwekuita kweCatalytic:
Nharembozha/Wechat/WhatsApp: +86-13681683526
Tsamba yemagetsi:lchen@syncozymes.com
| MaEnzayimu | Kodhi Yechigadzirwa | Tsanangudzo |
| Upfu hweEnzimu | ES-IRED-101~ ES-IRED-114 | seti ye14 Imine Reductase, 50 mg imwe neimwe |
| Kiti Yekuongorora MaEnzyme e96-Well | ES-IRED-1400 | seti ye14 Imine Reductase, 1 mg imwe neimwe |
★ Hunhu hwepamusoro hwe substrate.
★ Kusarudza kwakasimba kwerudo rwechikara.
★ Kuchinja kwakanyanya.
★ Zvibereko zvishoma.
★ Mamiriro ekuita zvinhu zvisina kusimba.
★ Inochengetedza zvakatipoteredza.
➢ Kazhinji, nzira yekugadzirira inofanira kusanganisira substrate, buffer solution, enzyme, coenzyme, uye coenzyme regeneration system.
➢ Mhando dzese dzeES-IREDs dzinoenderana nemamiriro akasiyana-siyana ekuita zvakanaka dzinofanira kudzidzwa imwe neimwe.
➢ Substrate yakawanda kana chigadzirwa chine substrate chinogona kukanganisa mashandiro eES-IRED. Zvisinei, kudziviswa uku kunogona kuderedzwa nekuwedzera substrate.
Muenzaniso 1 (Kugadzira chiral 2-methyl pyrrolidine)(1):
Muenzaniso 2 (Biosynthesis ye secondary amine)(2):
Muenzaniso 3 (Kuderedzwa kweCyclic Imines)(3):
Chengeta kwemakore maviri pasi pe -20℃.
Usambosangana nemamiriro ezvinhu akaipisisa akadai se: tembiricha yakakwira, pH yakakwira/yakaderera uye organic solvent yakakwira.
1. Scheller PN, Fademrecht S, Hofelzer S, nevamwe. ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, nevamwe. ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, nevamwe. Adv. Synth. Catal. 2015, 357, 1692-1696.
